Technology Process of 6-Octenoic acid, 5,8-dihydroxy-2-(phenylsulfonyl)-, methyl ester,
(5R,6E)-
There total 5 articles about 6-Octenoic acid, 5,8-dihydroxy-2-(phenylsulfonyl)-, methyl ester,
(5R,6E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
camphor-10-sulfonic acid;
In
methanol;
for 5h;
DOI:10.1021/ol0363366
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 99 percent / triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 0 - 20 °C
2.1: 96 percent / DIBAL / CH2Cl2; toluene / -78 - -40 °C
3.1: 100 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 3 h / 20 °C
4.1: sodium hydride / dimethylformamide; various solvent(s) / 2 h
4.2: 87 percent / dimethylformamide; various solvent(s) / 15 h / Heating
5.1: 92 percent / camphorsulfonic acid / methanol / 5 h
With
dmap; camphor-10-sulfonic acid; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; triethylamine;
In
methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol0363366
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 100 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 3 h / 20 °C
2.1: sodium hydride / dimethylformamide; various solvent(s) / 2 h
2.2: 87 percent / dimethylformamide; various solvent(s) / 15 h / Heating
3.1: 92 percent / camphorsulfonic acid / methanol / 5 h
With
camphor-10-sulfonic acid; pyridinium p-toluenesulfonate; sodium hydride;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol0363366
