Carbamic acid, [(1S,2S,4R)-2-hydroxy-4-methyl-5-[[(1S)-2-methyl-1-[[(4-pyridinylmethyl) amino]carbonyl]propyl]amino]-5-oxo-1-(phenylmethyl)pentyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [(1S,2S,4R)-2-hydroxy-4-methyl-5-[[(1S)-2-methyl-1-[[(4-pyridinylmethyl) amino]carbonyl]propyl]amino]-5-oxo-1-(phenylmethyl)pentyl]-, 1,1-dimethylethyl ester
CAS No.:669083-16-3
Molecular Formula:C29H42N4O5
Molecular Weight:526.676
Hs Code.:

Carbamic acid,
[(1S,2S,4R)-2-hydroxy-4-methyl-5-[[(1S)-2-methyl-1-[[(4-pyridinylmethyl)
amino]carbonyl]propyl]amino]-5-oxo-1-(phenylmethyl)pentyl]-,
1,1-dimethylethyl ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbamic acid, [(1S,2S,4R)-2-hydroxy-4-methyl-5-[[(1S)-2-methyl-1-[[(4-pyridinylmethyl) amino]carbonyl]propyl]amino]-5-oxo-1-(phenylmethyl)pentyl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of Carbamic acid, [(1S,2S,4R)-2-hydroxy-4-methyl-5-[[(1S)-2-methyl-1-[[(4-pyridinylmethyl) amino]carbonyl]propyl]amino]-5-oxo-1-(phenylmethyl)pentyl]-, 1,1-dimethylethyl ester

There total 3 articles about Carbamic acid, [(1S,2S,4R)-2-hydroxy-4-methyl-5-[[(1S)-2-methyl-1-[[(4-pyridinylmethyl) amino]carbonyl]propyl]amino]-5-oxo-1-(phenylmethyl)pentyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 669083-01-6
((1S,2S,4R)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-4-{(S)-2-methyl-1-[(pyridin-4-ylmethyl)-carbamoyl]-propylcarbamoyl}-pentyl)-carbamic acid tert-butyl ester

: 669083-16-3
((1S,2S,4R)-1-Benzyl-2-hydroxy-4-{(S)-2-methyl-1-[(pyridin-4-ylmethyl)-carbamoyl]-propylcarbamoyl}-pentyl)-carbamic acid tert-butyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2003.09.084

Reference yield:

: 123482-69-9
(2R,4S,5S)-5-tert-butoxycarbonylamino-4-(tert-butyldimethylsilyloxy)-2-methyl-6-phenylhexanoic acid

: 669083-16-3
((1S,2S,4R)-1-Benzyl-2-hydroxy-4-{(S)-2-methyl-1-[(pyridin-4-ylmethyl)-carbamoyl]-propylcarbamoyl}-pentyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / HOBt; EDCI / tetrahydrofuran

2: 90 percent / TBAF / tetrahydrofuran

With tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2003.09.084

Reference yield:

: 1236264-29-1
2-amino-3-methyl-N-pyridin-4-ylmethyl-butyramide; compound with GENERIC INORGANIC NEUTRAL COMPONENT

: 669083-16-3
((1S,2S,4R)-1-Benzyl-2-hydroxy-4-{(S)-2-methyl-1-[(pyridin-4-ylmethyl)-carbamoyl]-propylcarbamoyl}-pentyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / HOBt; EDCI / tetrahydrofuran

2: 90 percent / TBAF / tetrahydrofuran

With tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2003.09.084