Carbamic acid, [(1S)-2-[(2,2-dimethoxyethyl)[(2-fluoro-5-nitrophenyl)methyl]amino]-1-[[4- (1,1-dimethylethoxy)phenyl]methyl]-2-oxoethyl]-, 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:Carbamic acid, [(1S)-2-[(2,2-dimethoxyethyl)[(2-fluoro-5-nitrophenyl)methyl]amino]-1-[[4- (1,1-dimethylethoxy)phenyl]methyl]-2-oxoethyl]-, 9H-fluoren-9-ylmethyl ester
CAS No.:669772-16-1
Molecular Formula:C39H42FN3O8
Molecular Weight:699.776
Hs Code.:

Carbamic acid,
[(1S)-2-[(2,2-dimethoxyethyl)[(2-fluoro-5-nitrophenyl)methyl]amino]-1-[[4-
(1,1-dimethylethoxy)phenyl]methyl]-2-oxoethyl]-, 9H-fluoren-9-ylmethyl
ester

Synonyms:

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Chemical Property of Carbamic acid, [(1S)-2-[(2,2-dimethoxyethyl)[(2-fluoro-5-nitrophenyl)methyl]amino]-1-[[4- (1,1-dimethylethoxy)phenyl]methyl]-2-oxoethyl]-, 9H-fluoren-9-ylmethyl ester

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Technology Process of Carbamic acid, [(1S)-2-[(2,2-dimethoxyethyl)[(2-fluoro-5-nitrophenyl)methyl]amino]-1-[[4- (1,1-dimethylethoxy)phenyl]methyl]-2-oxoethyl]-, 9H-fluoren-9-ylmethyl ester

There total 1 articles about Carbamic acid, [(1S)-2-[(2,2-dimethoxyethyl)[(2-fluoro-5-nitrophenyl)methyl]amino]-1-[[4- (1,1-dimethylethoxy)phenyl]methyl]-2-oxoethyl]-, 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 669772-16-1
(2S)-3-(4-tert-butoxyphenyl)-N-(2,2-dimethoxyethyl)-2-[(9-H-fluoren-9-ylmethoxycarbonyl)amino]-N-(2-fluoro-5-nitrobenzyl)propionamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: AcOH / methanol

1.2: 72 percent / NaCNBH₃ / methanol

2.1: 90 percent / HATU; DIEA / CH₂Cl₂

With acetic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; dichloromethane;
DOI:10.1021/jm030921v

Reference yield:

: 669772-16-1
(2S)-3-(4-tert-butoxyphenyl)-N-(2,2-dimethoxyethyl)-2-[(9-H-fluoren-9-ylmethoxycarbonyl)amino]-N-(2-fluoro-5-nitrobenzyl)propionamide

: [7-amino-2-(4-hydroxy-benzyl)-3-oxo-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 3.98 g / DBU / tetrahydrofuran / 2 h

2: 2.55 g / Et₃N / dimethylsulfoxide; H₂O / 72 h / 20 °C

3: TFA / CH₂Cl₂

4: 249 mg / NaClO₂; aq. NaH₂PO₄; cyclohexene / 2-methyl-propan-2-ol; tetrahydrofuran / 0.75 h / 0 °C

5: HCO₂NH₄ / Pd/C / methanol / 3 h

With sodium chlorite; sodium dihydrogenphosphate; ammonium formate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; cyclohexene; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol;
DOI:10.1021/jm030921v