1-(3,5-dimethoxyphenyl)-1H-pyrrole-2,5-dione

Base Information

• Chemical Name: 1-(3,5-dimethoxyphenyl)-1H-pyrrole-2,5-dione
• CAS No.: 67154-43-2
• Molecular Formula: C12H11NO4
• Molecular Weight: 233.224
• DSSTox Substance ID: DTXSID301259320
• Mol file: 67154-43-2.mol

Synonyms:1-(3,5-dimethoxyphenyl)-1H-pyrrole-2,5-dione;67154-43-2;1-(3,5-dimethoxyphenyl)pyrrole-2,5-dione;1-(3,5-dimethoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione;Cyto9G8;Maybridge1_007270;SCHEMBL11350785;HMS562C10;DTXSID301259320;MFCD00176584;STL582023;AKOS000249027;LS-05733;CS-0319589

Chemical Property of 1-(3,5-dimethoxyphenyl)-1H-pyrrole-2,5-dione

Chemical Property:

• Melting Point: 121.8 °C
• PSA: 55.84000
• LogP: 1.19820
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 233.06880783
• Heavy Atom Count: 17
• Complexity: 322

Purity/Quality:

98%min ^*data from raw suppliers

1-(3,5-Dimethoxyphenyl)-1H-pyrrole-2,5-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1)N2C(=O)C=CC2=O)OC

Technology Process of 1-(3,5-dimethoxyphenyl)-1H-pyrrole-2,5-dione

There total 4 articles about 1-(3,5-dimethoxyphenyl)-1H-pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

maleic anhydride (108-31-6) + 3.5-dimethoxyaniline (10272-07-8) → 1‐(3,5‐dimethoxyphenyl)‐1H‐pyrrole‐2,5‐dione (67154-43-2)

Guidance literature:

With acetic acid; at 120 ℃;

DOI:10.1055/s-0037-1610713

Reference yield:

3.5-dimethoxyaniline (10272-07-8) → 1‐(3,5‐dimethoxyphenyl)‐1H‐pyrrole‐2,5‐dione (67154-43-2)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 1 h / Reflux

2: sodium acetate; acetic anhydride / 0.5 h

With sodium acetate; acetic anhydride; In diethyl ether;

DOI:10.3390/ph13010016

Reference yield:

C12H13NO5 → 1‐(3,5‐dimethoxyphenyl)‐1H‐pyrrole‐2,5‐dione (67154-43-2)

Guidance literature:

With sodium acetate; acetic anhydride; for 0.5h;

DOI:10.3390/ph13010016

upstream raw materials:

3.5-dimethoxyaniline

maleic anhydride

Downstream raw materials:

7-(3,5-dimethoxyphenyl)-2,3,7-triazabicyclo[3.3.0]oct-2-ene-6,8-dione

6-exo-t-butyl-3-(3,5-dimethoxyphenyl)-6-phenyl-3-azabicyclo-[3.1.0]hexane-2,4-dione

C₁₃H₁₃NO₄

C₁₃H₁₃NO₄