10-aminocamptothecin

Base Information

Chemical Name:10-aminocamptothecin
CAS No.:130194-90-0
Molecular Formula:C₂₀H₁₇N₃O₄
Molecular Weight:363.373
Hs Code.:
Mol file:130194-90-0.mol

Synonyms:1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,10-amino-4-ethyl-4-hydroxy-, (?à)-; (?à)-9-Aminocamptothecine;9-Amino-20(RS)-camptothecin; NSC 629971

Suppliers and Price of 10-aminocamptothecin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 10-aminocamptothecin

Chemical Property:

Vapor Pressure:2.01E-28mmHg at 25°C
Boiling Point:819.6°Cat760mmHg
Flash Point:449.5°C
PSA：107.44000
Density:1.55g/cm³
LogP:2.24300

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 10-aminocamptothecin

There total 7 articles about 10-aminocamptothecin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 120665-14-7
9-nitro-(20RS)-camptothecin

: 130194-90-0
9-amino-(20RS)-camptothecin

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 20h; under 760 Torr;
DOI:10.1021/jm00070a013

Reference yield:

: 606-31-5
2,6-dinitrobenzaldehyde

: 130194-90-0
9-amino-(20RS)-camptothecin

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / p-TsOH*H₂O / toluene / 4.5 h / Heating

2: 90 percent / Na₂S*9H₂O / ethanol; H₂O / 0.5 h / Heating

3: 89 percent / 2N aq. H₂SO₄ / tetrahydrofuran / 1 h

4: 86 percent / conc. HCl, glacial AcOH / 4 h / Heating

5: 65 percent / H₂ / 10percent Pd/C / ethanol / 20 h / 760 Torr

With hydrogenchloride; sodium sulfide; sulfuric acid; hydrogen; toluene-4-sulfonic acid; acetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; toluene;
DOI:10.1021/jm00070a013

Reference yield:

: 102978-40-5
4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

: 130194-90-0
9-amino-(20RS)-camptothecin

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / conc. HCl, glacial AcOH / 4 h / Heating

2: 65 percent / H₂ / 10percent Pd/C / ethanol / 20 h / 760 Torr

With hydrogenchloride; hydrogen; acetic acid; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00070a013