Alteplase

Base Information

• Chemical Name: Alteplase
• CAS No.: 105857-23-6
• Molecular Weight: 0

Synonyms:Alteplase;Activase (tn);Alteplase (genetical recombination);Alteplase (genetical recombination) (jan);Alteplase (usp/inn);D02837;PlasMinogen activator (huMan tissue-type protein Moiety) (9CI)

Chemical Property of Alteplase

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

98% ,99% , ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

• Description: Alteplase is a recombinant single-chain tissue plasminogen activator useful in the management of thrombosis in acute myocardial infarct. It reportedly causes no allergic reactions but requires intravenous infusion due to a short half-life. Alteplase is the only agent on the U.S. market indicated for the reduction of incidence of congestive heart failure following a heart attack.
• Uses: Tissue-type plasminogen activator; fibrinolytic.
• Clinical Use: Alteplase (tPA) is a serine protease with a low affinity for free plasminogen but a very high affinity for the plasminogen bound to fibrin in a thrombus (fibrin-specific agent). Both streptokinase and urokinase lack this specificity (i.e., are nonspecific) and act on free plasminogen, inducing a generalized thrombolytic state. Alteplase also has a greater specificity for older clots compared with newer clots relative to streptokinase and urokinase. Alteplase was originally isolated from cultures of human melanoma cells but is now produced commercially using recombinant DNA technology.

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