Chemical Property of Alteplase
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Chemical Property:
- Purity/Quality:
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98%Min *data from raw suppliers
Safty Information:
- Pictogram(s):
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- MSDS Files:
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Useful:
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Description
Alteplase is a recombinant single-chain tissue plasminogen activator useful in the
management of thrombosis in acute myocardial infarct. It reportedly causes no allergic
reactions but requires intravenous infusion due to a short half-life. Alteplase is the only
agent on the U.S. market indicated for the reduction of incidence of congestive heart
failure following a heart attack.
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Uses
Tissue-type plasminogen activator; fibrinolytic.
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Clinical Use
Alteplase (tPA) is a serine protease with a low affinity for free plasminogen but a very high affinity
for the
plasminogen bound to fibrin in a thrombus (fibrin-specific agent). Both streptokinase
and urokinase lack this specificity (i.e., are nonspecific) and act on free plasminogen, inducing a
generalized thrombolytic state. Alteplase also has a greater specificity for older clots compared with
newer clots relative to streptokinase and urokinase. Alteplase was originally isolated from cultures
of human melanoma cells but is now produced commercially using recombinant DNA technology.
