4-Hydroxyisophthalic acid

Base Information

Chemical Name:4-Hydroxyisophthalic acid
CAS No.:636-46-4
Molecular Formula:C8H6O5
Molecular Weight:182.133
Hs Code.:29182900
European Community (EC) Number:211-258-0
NSC Number:2445
UNII:P87FF77O00
DSSTox Substance ID:DTXSID50862332
Nikkaji Number:J94.855A
Wikidata:Q27286362
Mol file:636-46-4.mol

Synonyms:4-HIPA;4-hydroxy-iso-phthalate;4-hydroxy-isophthalate;4-hydroxyisophthalic acid

Suppliers and Price of 4-Hydroxyisophthalic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Hydroxyisophthalic Acid
25g
$ 425.00

TCI Chemical
4-Hydroxyisophthalic Acid >98.0%(HPLC)(T)
5g
$ 56.00

TCI Chemical
4-Hydroxyisophthalic Acid >98.0%(HPLC)(T)
25g
$ 204.00

Sigma-Aldrich
Salicylic acid impurity B European Pharmacopoeia (EP) Reference Standard
y0000405
$ 190.00

Sigma-Aldrich
4-Hydroxyisophthalic Acid(Salicylic Acid RCB) Pharmaceutical Secondary Standard; Certified Reference Material
200mg
$ 131.00

Sigma-Aldrich
Salicylic acid Related Compound B United States Pharmacopeia (USP) Reference Standard
100mg
$ 126.00

Sigma-Aldrich
4-Hydroxyisophthalic acid 95%
250 mg
$ 112.00

Sigma-Aldrich
4-Hydroxyisophthalic acid 95%
250mg
$ 107.00

Oakwood
4-Hydroxyisophthalic Acid 98%
5g
$ 50.00

Matrix Scientific
4-Hydroxyisophthalic acid 95%
100g
$ 955.00

Total 79 raw suppliers

Chemical Property of 4-Hydroxyisophthalic acid

Chemical Property:

Appearance/Colour:White powder
Vapor Pressure:8.58E-09mmHg at 25°C
Melting Point:>300°C
Refractive Index:1.5690 (estimate)
Boiling Point:447.5 °C at 760 mmHg
PKA:2?+-.0.10(Predicted)
Flash Point:238.6 °C
PSA：94.83000
Density:1.612 g/cm³
LogP:0.78860
Storage Temp.:2-8°C
Solubility.:DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
Water Solubility.:0.3g/L(24 oC)
XLogP3:1.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:182.02152329
Heavy Atom Count:13
Complexity:225

Purity/Quality:

≥98% ^*data from raw suppliers

4-Hydroxyisophthalic Acid ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi,Xn
Statements: 36/37/38-41-22-36/38
Safety Statements: 26-36/37/39-36-39-6

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1C(=O)O)C(=O)O)O
Uses 4-Hydroxyisophthalic acid has been proposed as an improvement over aspirin. An impurity of Acetylsalicylic acid (A187780). 4-Hydroxyisophthalic acid has been proposed as an improvement over aspirin. An impurity of Acetylsalicylic acid (A187780). Acetylsalicylic Acid Impurity B; Aspirin Impurity B

Technology Process of 4-Hydroxyisophthalic acid

There total 88 articles about 4-Hydroxyisophthalic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 6939-93-1
4-bromo-isophthalic acid

: 636-46-4
4-hydroxyisophthalic acid

Guidance literature:: With water; sodium carbonate; N,N,N,N,-tetramethylethylenediamine; copper(I) bromide; at 85 ℃; for 18h;

Reference yield: 95.0%

: 63296-13-9
4-benzyloxy-isophthalic acid

: 636-46-4
4-hydroxyisophthalic acid

Guidance literature:: With sodium hypophosphite; palladium on activated charcoal; In ethanol; water; for 2.5h; Heating;
DOI:10.1016/S0040-4039(01)81494-5