Chemical Property of [3-Amino-1-hydroxy-1-[hydroxy(oxido)phosphoryl]propyl]-hydroxyphosphinate; sodium; pentahydrate
Chemical Property:
- Appearance/Colour:white to off-white crystalline powder
- Vapor Pressure:3.79E-20mmHg at 25°C
- Melting Point:300℃
- Boiling Point:658.7 °C at 760 mmHg
- Flash Point:352.2 °C
- PSA：232.74000
- LogP:-0.40810
- Storage Temp.:2-8°C
- Solubility.:Soluble in water, practically insoluble in methylene chloride. It is sparingly soluble in dilute mineral acids and dissolves in dilute alkaline solutions.
- Hydrogen Bond Donor Count:9
- Hydrogen Bond Acceptor Count:13
- Rotatable Bond Count:4
- Exact Mass:369.01778760
- Heavy Atom Count:20
- Complexity:238
- Purity/Quality:
-
99% *data from raw suppliers
Pamedronatedisodiumsalt 98% *data from reagent suppliers
Safty Information:
- Pictogram(s):
R22:;
- Hazard Codes:
Xn:Harmful;
- Statements:
R22:;
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C(CN)C(O)(P(=O)(O)[O-])P(=O)(O)[O-].O.O.O.O.O.[Na].[Na]
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Uses
Pamidronate Disodium Salt Pentahydrate is a calcium metabolism regulator. Bone resorption inhibitor.
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Therapeutic Function
Bone resorption suppressant
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Clinical Use
Pamidronate, a second-generation bisphosphonate, is 100-fold more potent than etidronate. It
has been approved for the treatment of hypercalcemia of malignancy, for Paget's disease, and for osteolytic
bone metastases of breast cancer and osteolytic lesions of multiple myeloma. When used to treat bone
metastases, pamidronate decreases osteoclast recruitment, decreases osteoclast activity and increases
osteoclast apoptosis. Erosive esophagitis has been reported with the use of pamidronate sodium.
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Drug interactions
Potentially hazardous interactions with other drugsNone known
