Benzaldehyde, 2-hydroxy-4-(2-propynyloxy)-

Base Information

• Chemical Name: Benzaldehyde, 2-hydroxy-4-(2-propynyloxy)-
• CAS No.: 67268-54-6
• Molecular Formula: C10H8O3
• Molecular Weight: 176.172
• Mol file: 67268-54-6.mol

Synonyms:4-propargyloxy-2-hydroxybenzaldehyde;(formyl-4 hydroxy-3 phenoxy)-3 propyne-1;2-hydroxy-4-(prop-2-ynyloxy)benzaldehyde;4-propynoxysalicylaldehyde;2-Hydroxy-4-prop-2-ynyloxy-benzaldehyde;

Chemical Property of Benzaldehyde, 2-hydroxy-4-(2-propynyloxy)-

Chemical Property:

• Melting Point: 72 °C
• PSA: 46.53000
• LogP: 1.21670

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzaldehyde, 2-hydroxy-4-(2-propynyloxy)-

There total 4 articles about Benzaldehyde, 2-hydroxy-4-(2-propynyloxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

propargyl bromide (106-96-7) + 2,4-Dihydroxybenzaldehyde (95-01-2) → 2-hydroxy-4-(prop- 2-yn-1-yloxy)benzaldehyde (67268-54-6)

Guidance literature:

With potassium hydrogencarbonate; potassium iodide; In acetonitrile;

DOI:10.1016/j.poly.2013.02.030

Reference yield: 7.0%

propargyl bromide (106-96-7) + 2,4-Dihydroxybenzaldehyde (95-01-2) → 2-hydroxy-4-(prop- 2-yn-1-yloxy)benzaldehyde (67268-54-6) + 2,4-bis(prop-2-yn-1-yloxy)benzaldehyde (86236-18-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 2h; Heating;

Reference yield:

recorcinol (108-46-3) → 2-hydroxy-4-(prop- 2-yn-1-yloxy)benzaldehyde (67268-54-6)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / acetonitrile / 0 - 5 °C

2: potassium carbonate / acetone / 50 °C

With potassium carbonate; trichlorophosphate; In acetone; acetonitrile;

DOI:10.1021/ma502389w

upstream raw materials:

propargyl bromide

2,4-Dihydroxybenzaldehyde

recorcinol

Downstream raw materials:

2-isopropoxy-4-(prop-2-ynyloxy)benzaldehyde

(2R,3S,4S,5R,6S)-2-(acetoxymethyl)-6-(4-((2-formyl-5-(prop-2-yn-1-yloxy)phenoxy)methyl)phenoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate

4-(prop-2-ynyloxy)-2-(triisopropylsilyloxy)benzaldehyde

2-(allyloxy)-4-(prop-2-ynyloxy)benzaldehyde