4-Thiazolidinecarboxamide, 3-[(2S,3S)-3-amino-2-hydroxy-4-[4-(1-methylethoxy)phenyl]-1-oxobutyl]- 5,5-dimethyl-N-[(2-methylphenyl)methyl]-, (4R)-

Base Information

Chemical Name:4-Thiazolidinecarboxamide, 3-[(2S,3S)-3-amino-2-hydroxy-4-[4-(1-methylethoxy)phenyl]-1-oxobutyl]- 5,5-dimethyl-N-[(2-methylphenyl)methyl]-, (4R)-
CAS No.:672965-11-6
Molecular Formula:C₂₇H₃₇N₃O₄S
Molecular Weight:499.674
Hs Code.:

4-Thiazolidinecarboxamide,
3-[(2S,3S)-3-amino-2-hydroxy-4-[4-(1-methylethoxy)phenyl]-1-oxobutyl]-
5,5-dimethyl-N-[(2-methylphenyl)methyl]-, (4R)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Thiazolidinecarboxamide, 3-[(2S,3S)-3-amino-2-hydroxy-4-[4-(1-methylethoxy)phenyl]-1-oxobutyl]- 5,5-dimethyl-N-[(2-methylphenyl)methyl]-, (4R)-

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Technology Process of 4-Thiazolidinecarboxamide, 3-[(2S,3S)-3-amino-2-hydroxy-4-[4-(1-methylethoxy)phenyl]-1-oxobutyl]- 5,5-dimethyl-N-[(2-methylphenyl)methyl]-, (4R)-

There total 4 articles about 4-Thiazolidinecarboxamide, 3-[(2S,3S)-3-amino-2-hydroxy-4-[4-(1-methylethoxy)phenyl]-1-oxobutyl]- 5,5-dimethyl-N-[(2-methylphenyl)methyl]-, (4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [(1S,2S)-3-[(R)-5,5-Dimethyl-4-(2-methyl-benzylcarbamoyl)-thiazolidin-3-yl]-2-hydroxy-1-(4-isopropoxy-benzyl)-3-oxo-propyl]-carbamic acid tert-butyl ester

: 672965-11-6
(R)-N-(2-methylbenzyl)-3-[(2S,3S)-3-amino-2-hydroxy-4-(4-isopropoxyphenyl)butanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Guidance literature:: With hydrogenchloride; In ethyl acetate;
DOI:10.1016/j.bmc.2003.10.037

Reference yield:

: 89-93-0
ortho-methylbenzylamine

: 672965-11-6
(R)-N-(2-methylbenzyl)-3-[(2S,3S)-3-amino-2-hydroxy-4-(4-isopropoxyphenyl)butanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: diphenyl phosphorochloridate; triethylamine / ethyl acetate / 1 h / cooling

1.2: triethylamine / ethyl acetate / cooling

2.1: 3.75 g / HCl / CH₂Cl₂; dioxane / 2 h

3.1: N,N'-dicyclohexylcarbodiimide; 1-hydroxybenzotriazole / ethyl acetate

4.1: HCl / ethyl acetate

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; chlorophosphoric acid diphenyl ester; In 1,4-dioxane; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmc.2003.10.037

Reference yield:

: 117918-23-7
(R)-3-tert-butoxycarbonyl-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid

: 672965-11-6
(R)-N-(2-methylbenzyl)-3-[(2S,3S)-3-amino-2-hydroxy-4-(4-isopropoxyphenyl)butanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: diphenyl phosphorochloridate; triethylamine / ethyl acetate / 1 h / cooling

1.2: triethylamine / ethyl acetate / cooling

2.1: 3.75 g / HCl / CH₂Cl₂; dioxane / 2 h

3.1: N,N'-dicyclohexylcarbodiimide; 1-hydroxybenzotriazole / ethyl acetate

4.1: HCl / ethyl acetate

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; chlorophosphoric acid diphenyl ester; In 1,4-dioxane; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmc.2003.10.037