Technology Process of 2-(4-fluorophenyl)-1,4-dimethyl-5-nitro-imidazole
There total 3 articles about 2-(4-fluorophenyl)-1,4-dimethyl-5-nitro-imidazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 67 percent / HCl(g) / 144 h / 20 °C
2: 1.) glacial acetic acid, 2.) 5 N HCl / 1.) 100 deg C, 2 h, 2.) 100 deg C, 30 min
3: 52 percent / acetic anhydride, nitric acid / 0.25 h / 100 °C
4: 114 mg / 1,2-dimethoxy-ethane; diethyl ether / 1 h
With
hydrogenchloride; nitric acid; acetic anhydride; acetic acid;
In
1,2-dimethoxyethane; diethyl ether;
DOI:10.1021/jm00384a025
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) glacial acetic acid, 2.) 5 N HCl / 1.) 100 deg C, 2 h, 2.) 100 deg C, 30 min
2: 52 percent / acetic anhydride, nitric acid / 0.25 h / 100 °C
3: 114 mg / 1,2-dimethoxy-ethane; diethyl ether / 1 h
With
hydrogenchloride; nitric acid; acetic anhydride; acetic acid;
In
1,2-dimethoxyethane; diethyl ether;
DOI:10.1021/jm00384a025
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 52 percent / acetic anhydride, nitric acid / 0.25 h / 100 °C
2: 114 mg / 1,2-dimethoxy-ethane; diethyl ether / 1 h
With
nitric acid; acetic anhydride;
In
1,2-dimethoxyethane; diethyl ether;
DOI:10.1021/jm00384a025
