Hydrazinecarboxylic acid, 2-[[2-[(1,1-dimethylethoxy)carbonyl]-1-(2-methylpropyl)hydrazino]acetyl]- 2-(phenylmethyl)-, phenylmethyl ester

Base Information

• Chemical Name: Hydrazinecarboxylic acid, 2-[[2-[(1,1-dimethylethoxy)carbonyl]-1-(2-methylpropyl)hydrazino]acetyl]- 2-(phenylmethyl)-, phenylmethyl ester
• CAS No.: 674291-05-5
• Molecular Formula: C26H36N4O5
• Molecular Weight: 484.596
• Mol file: 674291-05-5.mol

Synonyms:

Chemical Property of Hydrazinecarboxylic acid, 2-[[2-[(1,1-dimethylethoxy)carbonyl]-1-(2-methylpropyl)hydrazino]acetyl]- 2-(phenylmethyl)-, phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Hydrazinecarboxylic acid, 2-[[2-[(1,1-dimethylethoxy)carbonyl]-1-(2-methylpropyl)hydrazino]acetyl]- 2-(phenylmethyl)-, phenylmethyl ester

There total 3 articles about Hydrazinecarboxylic acid, 2-[[2-[(1,1-dimethylethoxy)carbonyl]-1-(2-methylpropyl)hydrazino]acetyl]- 2-(phenylmethyl)-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

Nα-benzyl-Nα-Z hydrazine (135942-02-8) + (N'-tert-butoxycarbonyl-N-isobutyl-hydrazino)-acetic acid (357953-50-5) → N'-[2-(N-benzyl-N'-benzyloxycarbonyl-hydrazino)-2-oxo-ethyl]-N'-isobutyl-hydrazinecarboxylic acid tert-butyl ester (674291-05-5)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1021/jm049455f

Reference yield:

Nα-benzyl-Nα-Z hydrazine (135942-02-8) → N'-[2-(N-benzyl-N'-benzyloxycarbonyl-hydrazino)-2-oxo-ethyl]-N'-isobutyl-hydrazinecarboxylic acid tert-butyl ester (674291-05-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 5 h / 0 °C

2: 4.2 g / CHCl₃ / 24 h / Heating

With pyridine; In dichloromethane; chloroform;

DOI:10.1016/j.bmc.2003.09.018

Reference yield:

Nα-isobutyl-Nβ-Boc-hydrazine (57699-53-3) + N'-benzyl-N'-bromoacetyl-hydrazinecarboxylic acid benzyl ester (500022-30-0) → N'-[2-(N-benzyl-N'-benzyloxycarbonyl-hydrazino)-2-oxo-ethyl]-N'-isobutyl-hydrazinecarboxylic acid tert-butyl ester (674291-05-5)

Guidance literature:

In chloroform; for 24h; Heating;

DOI:10.1016/j.bmc.2003.09.018

upstream raw materials:

N^α-isobutyl-N^β-Boc-hydrazine

N'-benzyl-N'-bromoacetyl-hydrazinecarboxylic acid benzyl ester

N^α-benzyl-N^α-Z hydrazine

(N'-tert-butoxycarbonyl-N-isobutyl-hydrazino)-acetic acid

Downstream raw materials:

N'-(N-benzyl-hydrazinocarbonylmethyl)-N'-isobutyl-hydrazinecarboxylic acid tert-butyl ester

N'-benzyl-N'-[(N-isobutyl-hydrazino)-acetyl]-hydrazinecarboxylic acid benzyl ester