2,4(1H,3H)-Pyrimidinedione, 3-benzoyl-1-[3-[2,2-bis[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3,3- difluorocyclopropyl]propyl]-5-fluoro-

Base Information

Chemical Name:2,4(1H,3H)-Pyrimidinedione, 3-benzoyl-1-[3-[2,2-bis[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3,3- difluorocyclopropyl]propyl]-5-fluoro-
CAS No.:674293-57-3
Molecular Formula:C₃₁H₄₇F₃N₂O₅Si₂
Molecular Weight:640.891
Hs Code.:

2,4(1H,3H)-Pyrimidinedione,
3-benzoyl-1-[3-[2,2-bis[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3,3-
difluorocyclopropyl]propyl]-5-fluoro-

Synonyms:

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Chemical Property of 2,4(1H,3H)-Pyrimidinedione, 3-benzoyl-1-[3-[2,2-bis[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3,3- difluorocyclopropyl]propyl]-5-fluoro-

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Technology Process of 2,4(1H,3H)-Pyrimidinedione, 3-benzoyl-1-[3-[2,2-bis[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3,3- difluorocyclopropyl]propyl]-5-fluoro-

There total 6 articles about 2,4(1H,3H)-Pyrimidinedione, 3-benzoyl-1-[3-[2,2-bis[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3,3- difluorocyclopropyl]propyl]-5-fluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [2,2-bis(benzyloxymethyl)-3,3-difluoro-cyclopropyl]methanol

: 674293-57-3
(+/-)-3-benzoyl-1-[(2,2-bis(tert-butyldimethylsilyloxymethyl)-3,3-difluoro-cyclopropyl)propyl]-5-fluoro-1,2,3,4-tetrahydro-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: 91 percent / 2,2,6,6-tetramethylpiperidine-1-oxyl radical; aq. KBr; NaOCl / CH₂Cl₂ / 0.17 h / 10 - 15 °C

2.1: NaH / toluene / 20 °C

2.2: 92 percent / toluene / 0.75 h

3.1: 83 percent / H₂ / Pearlman's catalyst / methanol / 20 °C

4.1: 89 percent / DMAP; pyridine / CH₂Cl₂ / 48 h / 20 °C

5.1: 86 percent / DIBAH / toluene / 2 h / -40 °C

6.1: PPh₃; diisopropyl azodicarboxylate / dioxane

With pyridine; dmap; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; di-isopropyl azodicarboxylate; hydrogen; sodium hydride; diisobutylaluminium hydride; triphenylphosphine; potassium bromide; palladium dihydroxide; In 1,4-dioxane; methanol; dichloromethane; toluene; 2.2: Emmons-Horner reaction / 6.1: Mitsunobu reaction;
DOI:10.1515/znb-2003-0907

Reference yield:

: 674293-46-0
(+/-)-[2,2-bis(benzyloxymethyl)-3,3-difluoro-cyclopropane]carbaldehyde

: 674293-57-3
(+/-)-3-benzoyl-1-[(2,2-bis(tert-butyldimethylsilyloxymethyl)-3,3-difluoro-cyclopropyl)propyl]-5-fluoro-1,2,3,4-tetrahydro-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / toluene / 20 °C

1.2: 92 percent / toluene / 0.75 h

2.1: 83 percent / H₂ / Pearlman's catalyst / methanol / 20 °C

3.1: 89 percent / DMAP; pyridine / CH₂Cl₂ / 48 h / 20 °C

4.1: 86 percent / DIBAH / toluene / 2 h / -40 °C

5.1: PPh₃; diisopropyl azodicarboxylate / dioxane

With pyridine; dmap; di-isopropyl azodicarboxylate; hydrogen; sodium hydride; diisobutylaluminium hydride; triphenylphosphine; palladium dihydroxide; In 1,4-dioxane; methanol; dichloromethane; toluene; 1.2: Emmons-Horner reaction / 5.1: Mitsunobu reaction;
DOI:10.1515/znb-2003-0907

Reference yield:

: (+/-)-ethyl [2,2-bis(benzyloxymethyl)-3,3-difluoro-cyclopropyl]propenoate

: 674293-57-3
(+/-)-3-benzoyl-1-[(2,2-bis(tert-butyldimethylsilyloxymethyl)-3,3-difluoro-cyclopropyl)propyl]-5-fluoro-1,2,3,4-tetrahydro-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / H₂ / Pearlman's catalyst / methanol / 20 °C

2: 89 percent / DMAP; pyridine / CH₂Cl₂ / 48 h / 20 °C

3: 86 percent / DIBAH / toluene / 2 h / -40 °C

4: PPh₃; diisopropyl azodicarboxylate / dioxane

With pyridine; dmap; di-isopropyl azodicarboxylate; hydrogen; diisobutylaluminium hydride; triphenylphosphine; palladium dihydroxide; In 1,4-dioxane; methanol; dichloromethane; toluene; 4: Mitsunobu reaction;
DOI:10.1515/znb-2003-0907