Acetic acid, [4-[[[[[3-[[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]amino]propyl][3 -[(trifluoroacetyl)amino]propyl]amino]carbonyl]oxy]methyl]phenoxy]-

Base Information

• Chemical Name: Acetic acid, [4-[[[[[3-[[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]amino]propyl][3 -[(trifluoroacetyl)amino]propyl]amino]carbonyl]oxy]methyl]phenoxy]-
• CAS No.: 674298-02-3
• Molecular Formula: C28H36F3N3O8
• Molecular Weight: 599.604
• Mol file: 674298-02-3.mol

Synonyms:

Chemical Property of Acetic acid, [4-[[[[[3-[[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]amino]propyl][3 -[(trifluoroacetyl)amino]propyl]amino]carbonyl]oxy]methyl]phenoxy]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetic acid, [4-[[[[[3-[[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]amino]propyl][3 -[(trifluoroacetyl)amino]propyl]amino]carbonyl]oxy]methyl]phenoxy]-

There total 3 articles about Acetic acid, [4-[[[[[3-[[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]amino]propyl][3 -[(trifluoroacetyl)amino]propyl]amino]carbonyl]oxy]methyl]phenoxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

N1-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-N5-(4-(allyloxycarbonylmethoxy)phenyl-methoxycarbonyl)-(N9-trifluoroacetyl)-norspermidine (674298-00-1) → N1-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-N5-(4-(carboxymethyl)phenyl-methoxycarbonyl)-(N9-trifluoroacetyl)-norspermidine (674298-02-3)

Guidance literature:

With thiosalicilyc acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; for 2h;

DOI:10.1002/chem.200305232

Reference yield:

N-[3-(3-amino-propylamino)-propyl]-2,2,2-trifluoro-acetamide → N1-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-N5-(4-(carboxymethyl)phenyl-methoxycarbonyl)-(N9-trifluoroacetyl)-norspermidine (674298-02-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 61 percent / CH₂Cl₂ / 12 h

2: 88 percent / dimethylformamide / 12 h

3: 72 percent / thiosalicylic acid / [Pd(PPh₃)4] / CH₂Cl₂; tetrahydrofuran / 2 h

With thiosalicilyc acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/chem.200305232

Reference yield:

N1-(trifluoroacetyl)-N9-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-norspermidine (674297-96-2) → N1-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-N5-(4-(carboxymethyl)phenyl-methoxycarbonyl)-(N9-trifluoroacetyl)-norspermidine (674298-02-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / dimethylformamide / 12 h

2: 72 percent / thiosalicylic acid / [Pd(PPh₃)4] / CH₂Cl₂; tetrahydrofuran / 2 h

With thiosalicilyc acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/chem.200305232

upstream raw materials:

N¹-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-N⁵-(4-(allyloxycarbonylmethoxy)phenyl-methoxycarbonyl)-(N⁹-trifluoroacetyl)-norspermidine

N¹-(trifluoroacetyl)-N⁹-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-norspermidine