14-chlorodaunorubicin

Base Information

• Chemical Name: 14-chlorodaunorubicin
• CAS No.: 121250-06-4
• Molecular Formula: C27H28 Cl N O10
• Molecular Weight: 561.96
• Mol file: 121250-06-4.mol

Synonyms:5,12-Naphthacenedione,10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-8-(chloroacetyl)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-,(8S,10S)- (9CI); 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-8-(chloroacetyl)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-,(8S-cis)-; 14-Chlorodaunomycin; 14-Chlororubomycin

Chemical Property of 14-chlorodaunorubicin

Chemical Property:

• Vapor Pressure: 1.43E-26mmHg at 25°C
• Boiling Point: 793.8°Cat760mmHg
• Flash Point: 433.9°C
• PSA: 185.84000
• Density: 1.6g/cm³
• LogP: 1.94810

Purity/Quality:

97% ^*data from raw suppliers

14-Chloro daunorubicin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 14-Chloro Daunorubicin belongs to adriamycin analogue，it is used as an anticancer agent. Adriamycin analogue; use as anticancer agent.

Technology Process of 14-chlorodaunorubicin

There total 1 articles about 14-chlorodaunorubicin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

daunomycin hydrochloride (23541-50-6) → 14-chlorodaunorubicine hydrobromide (121250-06-4) + 14-bromodaunorubicin (65026-79-1)

Guidance literature:

daunomycin hydrochloride; With bromine; trimethyl orthoformate; In 1,4-dioxane; methanol; at 11 ℃; for 2h; Inert atmosphere;

With methyloxirane; In 1,4-dioxane; methanol; at 4 ℃; for 1.25h; Inert atmosphere;

With hydrogen bromide; In 1,4-dioxane; methanol; acetone; at 20 ℃; for 48h; Inert atmosphere;

Reference yield: 44.0%

14-chlorodaunorubicine hydrobromide (121250-06-4) + 4-((3-((4-nitro-3-(trifluoromethyl)phenyl)(nitroso)amino)propyl)carbamoyl)benzoic acid + 14-bromodaunorubicin (65026-79-1) → C45H42F3N5O16*ClH

Guidance literature:

4-((3-((4-nitro-3-(trifluoromethyl)phenyl)(nitroso)amino)propyl)carbamoyl)benzoic acid; With potassium fluoride; In N,N-dimethyl-formamide; for 0.25h;

14-chlorodaunorubicine hydrobromide; 14-bromodaunorubicin; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; at 20 ℃; for 1h;

DOI:10.1039/d0cc02512g

upstream raw materials:

daunomycin hydrochloride

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