3-Thiophenecarboxylic acid, 2-[(phenylthio)methyl]-

Base Information

Chemical Name:3-Thiophenecarboxylic acid, 2-[(phenylthio)methyl]-
CAS No.:67443-41-8
Molecular Formula:C12H10O2S2
Molecular Weight:250.342
Hs Code.:

Synonyms:

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Chemical Property of 3-Thiophenecarboxylic acid, 2-[(phenylthio)methyl]-

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Technology Process of 3-Thiophenecarboxylic acid, 2-[(phenylthio)methyl]-

There total 7 articles about 3-Thiophenecarboxylic acid, 2-[(phenylthio)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.7%

: ethyl 2-((phenylthio)methyl)thiophene-3-carboxylate

: 67443-41-8
2-((phenylthio)methyl)thiophene-3-carboxylic acid

Guidance literature:: With methanol; sodium hydroxide; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 88-13-1
3-Thiophene carboxylic acid

: 67443-41-8
2-((phenylthio)methyl)thiophene-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 0.17 h / -78 °C

1.2: 1 h

1.3: 0.5 h

2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 50 °C

3.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.17 h / 20 °C / Cooling with ice

4.1: phosphorus tribromide / dichloromethane / 0.17 h / Cooling with ice

5.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / Cooling with ice

6.1: methanol; sodium hydroxide / tetrahydrofuran / 20 °C

With methanol; sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; phosphorus tribromide; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: ethyl 2-(bromomethyl)thiophene-3-carboxylate

: 67443-41-8
2-((phenylthio)methyl)thiophene-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / Cooling with ice

2: methanol; sodium hydroxide / tetrahydrofuran / 20 °C

With methanol; potassium carbonate; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;