2-NAPHTHALENAMINE, 1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-, HYDROCHLORIDE

Base Information

• Chemical Name: 2-NAPHTHALENAMINE, 1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-, HYDROCHLORIDE
• CAS No.: 67445-12-9
• Molecular Formula: C12H17NO2
• Molecular Weight: 207.26900
• Mol file: 67445-12-9.mol

Synonyms:6,7-dimethoxy-2-aminotetralin;2-amino-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalene;2-amino-6,7-dimethoxy tetraline;1,2,3,4-tetrahydro-6,7-dimethoxy-2-naphthylamine;1,2,3,4-tetrahydro-6,7-dimethoxy-2-naphtylamine;2-amino-6,7-dimethoxytetraline;

Chemical Property of 2-NAPHTHALENAMINE, 1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-, HYDROCHLORIDE

Chemical Property:

• PSA: 44.48000
• LogP: 2.22010

Purity/Quality:

97% ^*data from raw suppliers

6,7-Dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-NAPHTHALENAMINE, 1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-, HYDROCHLORIDE

There total 5 articles about 2-NAPHTHALENAMINE, 1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-, HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-benzylamino-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalene (66996-58-5) → 2-Amino-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalene (67445-12-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; under 1520 Torr;

DOI:10.1021/jm00206a023

Reference yield:

6,7-Dimethoxy-2-methoxyimino-1,2,3,4-Tetrahydronaphthalene → 2-Amino-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalene (67445-12-9)

Guidance literature:

With borane; In tetrahydrofuran;

Reference yield:

6,7-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-one (2472-13-1) → 2-Amino-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalene (67445-12-9)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) TsOH, benzene, (ii) H₂, PtO₂, EtOH

2: H₂ / Pd-C / ethanol / 1520 Torr

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00206a023

upstream raw materials:

2-benzylamino-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalene

6,7-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-one

3,4-dimethoxyphenylacetyl chloride

Downstream raw materials:

benzyl N-(6,7-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-yl)sulphamoylcarbamate