Haloprogesterone

Base Information

Chemical Name:Haloprogesterone
CAS No.:3538-57-6
Molecular Formula:C21H28BrFO2
Molecular Weight:411.3482
Hs Code.:
UNII:803BIX5JG5
ChEMBL ID:CHEMBL2104328
DSSTox Substance ID:DTXSID10188868
NCI Thesaurus Code:C74367
Nikkaji Number:J7.958H
Wikidata:Q19597398
Wikipedia:Haloprogesterone
Mol file:3538-57-6.mol

Synonyms:HALOPROGESTERONE;3538-57-6;803BIX5JG5;17-Bromo-6alpha-fluoropregn-4-ene-3,20-dione;Haloprogesterona;(6S,8R,9S,10R,13S,14S,17R)-17-acetyl-17-bromo-6-fluoro-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one;Haloprogesteronum;UNII-803BIX5JG5;Haloprogesterone [USAN:INN];17-Brom-6alpha-fluor-4-pregnen-3,20-dion;Haloprogesterone (USAN/INN);HALOPROGESTERONE [INN];SCHEMBL139523;HALOPROGESTERONE [USAN];CHEMBL2104328;DTXSID10188868;Pregn-4-ene-3,20-dione, 17-bromo-6-fluoro-, (6.alpha.)-;17alpha-Bromo-6alpha-fluoroprogesterone;D04414;17.ALPHA.-BROMO-6.ALPHA.-FLUOROPROGESTERONE;Pregn-4-ene-3,20-dione, 17-bromo-6-fluoro-, (6alpha)-

Suppliers and Price of Haloprogesterone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
HALOPROGESTERONE 95.00%
5MG
$ 499.92

Total 4 raw suppliers

Chemical Property of Haloprogesterone

Chemical Property:

Vapor Pressure:2.48E-09mmHg at 25°C
Boiling Point:478.9°Cat760mmHg
Flash Point:243.4°C
PSA：34.14000
Density:1.33g/cm³
LogP:5.18900
XLogP3:4.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:410.12567
Heavy Atom Count:25
Complexity:673

Purity/Quality:

99% ^*data from raw suppliers

HALOPROGESTERONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C1(CCC2C1(CCC3C2CC(C4=CC(=O)CCC34C)F)C)Br
Isomeric SMILES:CC(=O)[C@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C[C@@H](C4=CC(=O)CC[C@]34C)F)C)Br
Uses Progestin.

Technology Process of Haloprogesterone

There total 7 articles about Haloprogesterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3538-54-3
6β-Fluor-17α-brom-5α-hydroxy-pregnan-3,20-dion

: 3538-57-6
6α-Fluor-17α-brom-pregn-4-en-3,20-dion

Guidance literature:: With hydrogenchloride; In chloroform;
DOI:10.1139/v60-209

Reference yield:

: 2135-23-1
3β-acetoxy-6β-fluoro-5-hydroxy-5α-pregnan-20-one

: 3538-57-6
6α-Fluor-17α-brom-pregn-4-en-3,20-dion

Guidance literature:: Multi-step reaction with 4 steps

1: NBS / CCl₄ / Irradiation

2: aq. HClO₄ / methanol

3: aq. Na₂Cr₂O₇, AcOH

4: HCl / CHCl₃

With hydrogenchloride; N-Bromosuccinimide; perchloric acid; sodium dichromate; acetic acid; In methanol; tetrachloromethane; chloroform;
DOI:10.1139/v60-209

Reference yield:

: 1827-70-9
3β,5α-Dihydroxy-6β-fluor-17α-brom-pregnan-20-on

: 3538-57-6
6α-Fluor-17α-brom-pregn-4-en-3,20-dion

Guidance literature:: Multi-step reaction with 2 steps

1: aq. Na₂Cr₂O₇, AcOH

2: HCl / CHCl₃

With hydrogenchloride; sodium dichromate; acetic acid; In chloroform;
DOI:10.1139/v60-209