9-(4-chlorobenzylidene)-5-(4-chlorophenyl)-6,7,8,9-tetrahydro-5H-[1,3]thiazolo[2,3-b]quinazolin-3(2H)-one

Base Information

Chemical Name:9-(4-chlorobenzylidene)-5-(4-chlorophenyl)-6,7,8,9-tetrahydro-5H-[1,3]thiazolo[2,3-b]quinazolin-3(2H)-one
CAS No.:67533-99-7
Molecular Formula:C23H18Cl2N2OS
Molecular Weight:441.37300
Hs Code.:
Mol file:67533-99-7.mol

Synonyms:5-(4-Chloro-phenyl)-9-[1-(4-chloro-phenyl)-meth-(E)-ylidene]-6,7,8,9-tetrahydro-5H-thiazolo[2,3-b]quinazolin-3-one;

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Chemical Property of 9-(4-chlorobenzylidene)-5-(4-chlorophenyl)-6,7,8,9-tetrahydro-5H-[1,3]thiazolo[2,3-b]quinazolin-3(2H)-one

Chemical Property:

Melting Point:190 °C
PSA：57.97000
LogP:5.87460

Purity/Quality:

Safty Information:

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Technology Process of 9-(4-chlorobenzylidene)-5-(4-chlorophenyl)-6,7,8,9-tetrahydro-5H-[1,3]thiazolo[2,3-b]quinazolin-3(2H)-one

There total 5 articles about 9-(4-chlorobenzylidene)-5-(4-chlorophenyl)-6,7,8,9-tetrahydro-5H-[1,3]thiazolo[2,3-b]quinazolin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 79-11-8
chloroacetic acid

: 65331-28-4,833488-23-6
(8E)-8-(4-chlorobenzylidene)-4-(4-chlorophenyl)-3,4,5,6,7,8-hexahydroquinazoline-2(1H)thione

: 67533-99-7
(9E)-9-(4-chlorobenzylidene)?5-(4-chlorophenyl)?6,7,8,9-tetrahydro-2H-thiazolo[2,3-b]quinazolin-3(5H)-one

Guidance literature:: With sodium acetate; acetic acid; Mechanism; Reflux;
DOI:10.1080/17415993.2021.1971669

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 67533-99-7
(9E)-9-(4-chlorobenzylidene)?5-(4-chlorophenyl)?6,7,8,9-tetrahydro-2H-thiazolo[2,3-b]quinazolin-3(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / ethanol

2: potassium hydroxide / ethanol / 5 h / Reflux

3: acetic acid; sodium acetate / Reflux

With sodium acetate; acetic acid; potassium hydroxide; In ethanol; 1: |Claisen-Schmidt Condensation / 2: |Michael Addition;
DOI:10.1080/17415993.2021.1971669

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 67533-99-7
(9E)-9-(4-chlorobenzylidene)?5-(4-chlorophenyl)?6,7,8,9-tetrahydro-2H-thiazolo[2,3-b]quinazolin-3(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / ethanol

2: potassium hydroxide / ethanol / 5 h / Reflux

3: acetic acid; sodium acetate / Reflux

With sodium acetate; acetic acid; potassium hydroxide; In ethanol; 1: |Claisen-Schmidt Condensation / 2: |Michael Addition;
DOI:10.1080/17415993.2021.1971669