Acetamide, N-(4-chloro-2-(2-chlorobenzoyl)phenyl)-N-methyl-2-((((2-phenylethyl)amino)acetyl)amino)-, ethanedioate

Base Information

• Chemical Name: Acetamide, N-(4-chloro-2-(2-chlorobenzoyl)phenyl)-N-methyl-2-((((2-phenylethyl)amino)acetyl)amino)-, ethanedioate
• CAS No.: 59180-54-0
• Molecular Formula: C₂₆H₂₅Cl₂N₃O₃
• Molecular Weight: 498.409
• DSSTox Substance ID: DTXSID10207922
• Wikidata: Q83081936
• Mol file: 59180-54-0.mol

Synonyms:59180-54-0;Acetamide, N-(4-chloro-2-(2-chlorobenzoyl)phenyl)-N-methyl-2-((((2-phenylethyl)amino)acetyl)amino)-, ethanedioate;C26-H25-Cl2-N3-O3.C2-H2-O4;DTXSID10207922;C26H25Cl2N3O3.C2H2O4;LS-8451

Chemical Property of Acetamide, N-(4-chloro-2-(2-chlorobenzoyl)phenyl)-N-methyl-2-((((2-phenylethyl)amino)acetyl)amino)-, ethanedioate

Chemical Property:

• Vapor Pressure: 8.86E-19mmHg at 25°C
• Boiling Point: 688°Cat760mmHg
• Flash Point: 369.9°C
• Density: 1.319g/cm³
• XLogP3: 5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 9
• Exact Mass: 497.1272971
• Heavy Atom Count: 34
• Complexity: 701

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(CC(=O)N(CCC1=CC=CC=C1)C(=O)CN)C2=C(C=C(C=C2)Cl)C(=O)C3=CC=CC=C3Cl

Technology Process of Acetamide, N-(4-chloro-2-(2-chlorobenzoyl)phenyl)-N-methyl-2-((((2-phenylethyl)amino)acetyl)amino)-, ethanedioate

There total 2 articles about Acetamide, N-(4-chloro-2-(2-chlorobenzoyl)phenyl)-N-methyl-2-((((2-phenylethyl)amino)acetyl)amino)-, ethanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-(chloroacetyl)glycinanilide (59180-42-6) → N-({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-2-phenethylamino-acetamide (59180-54-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 91.5 percent / KI / acetone / 1 h / Heating

2: ethanol; CHCl₃; methanol / 3 h / Ambient temperature

With potassium iodide; In methanol; ethanol; chloroform; acetone;

DOI:10.1021/jm00133a006

Reference yield:

phenethylamine (64-04-0) + 4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-(iodoacetyl)glycinanilide (59180-43-7) → N-({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-2-phenethylamino-acetamide (59180-54-0)

Guidance literature:

In methanol; ethanol; chloroform; for 3h; Yield given; Ambient temperature;

DOI:10.1021/jm00133a006

upstream raw materials:

phenethylamine

4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(iodoacetyl)glycinanilide

4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(chloroacetyl)glycinanilide