Teuflin

Base Information

Chemical Name:Teuflin
CAS No.:72541-00-5
Molecular Formula:C19H20O5
Molecular Weight:328.3591
Hs Code.:
UNII:4ZX27K8S4X
Nikkaji Number:J11.260G
Wikidata:Q104393348
Mol file:72541-00-5.mol

Synonyms:Teuflin;Teuchamaedryn A;NSC-258598;6-epi-Teucvin;4ZX27K8S4X;AKOS040734459;NS00093848;(3R,5S,5'aS,7'R,8'aR)-5-(3-Furanyl)-3',4,5,5',5'a,7',8',8'a-octahydro-7'-methylspiro[furan-3(2H),6'-[6H]naphtho[1,8-bc]furan]-2,2'(4'H)-dione;Spiro[furan-3(2H),6'-[6H]naphtho[1,8-bc]furan]-2,2'(4'H)-dione, 5-(3-furanyl)-3',4,5,5',5'a,7',8',8'a-octahydro-7'-methyl-, (3R,5S,5'aS,7'R,8'aR)-

Suppliers and Price of Teuflin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Teuflin

Chemical Property:

Boiling Point:590.3°Cat760mmHg
Flash Point:310.8°C
PSA：65.74000
Density:1.34g/cm³
LogP:3.31590
XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:328.13107373
Heavy Atom Count:24
Complexity:638

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC2C3=C(CCCC3C14CC(OC4=O)C5=COC=C5)C(=O)O2
Isomeric SMILES:C[C@@H]1C[C@@H]2C3=C(CCC[C@@H]3[C@@]14C[C@H](OC4=O)C5=COC=C5)C(=O)O2

Technology Process of Teuflin

There total 10 articles about Teuflin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 22037-28-1
3-bromofurane

: 1378319-36-8
C₁₆H₂₀O₅

: 51918-98-0,55448-47-0,72541-00-5,75443-75-3,89617-43-6,125137-19-1,125137-20-4,53625-15-3
teucvidin

Guidance literature:: 3-bromofurane; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.5h;

C₁₆H₂₀O₅; In diethyl ether; hexane; at -78 ℃; for 0.333333h; stereoselective reaction;
DOI:10.1021/ol301098s

Reference yield:

: 1378319-20-0
C₁₆H₂₀O₃

: 51918-98-0,55448-47-0,72541-00-5,75443-75-3,89617-43-6,125137-19-1,125137-20-4,53625-15-3
teucvidin

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tetrahydrofuran; tert-butyl alcohol / 1 h / 0 - 20 °C

2.1: potassium hydroxide / diethyl ether; water / 0.5 h / 0 °C

3.1: ozone / dichloromethane / 0.17 h / -78 °C

3.2: 12 h / 325 °C

4.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -78 °C

4.2: 0.33 h / -78 °C

With sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; 2-methyl-but-2-ene; ozone; potassium hydroxide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; tert-butyl alcohol; 1.1: Pinnick oxidation;
DOI:10.1021/ol301098s

Reference yield:

: 1378319-21-1
C₁₇H₂₂O₄

: 51918-98-0,55448-47-0,72541-00-5,75443-75-3,89617-43-6,125137-19-1,125137-20-4,53625-15-3
teucvidin

Guidance literature:: Multi-step reaction with 2 steps

1.1: ozone / dichloromethane / 0.17 h / -78 °C

1.2: 12 h / 325 °C

2.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -78 °C

2.2: 0.33 h / -78 °C

With n-butyllithium; ozone; In diethyl ether; hexane; dichloromethane;
DOI:10.1021/ol301098s