2,8,17,23-Tetraazatetracosanedioic acid, 3,22-dicarboxy-9,16-dioxo-, 1,24-bis(phenylmethyl) ester, (3S,22S)-

Base Information

• Chemical Name: 2,8,17,23-Tetraazatetracosanedioic acid, 3,22-dicarboxy-9,16-dioxo-, 1,24-bis(phenylmethyl) ester, (3S,22S)-
• CAS No.: 675587-73-2
• Molecular Formula: C36H50N4O10
• Molecular Weight: 698.814
• Mol file: 675587-73-2.mol

Synonyms:

Chemical Property of 2,8,17,23-Tetraazatetracosanedioic acid, 3,22-dicarboxy-9,16-dioxo-, 1,24-bis(phenylmethyl) ester, (3S,22S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,8,17,23-Tetraazatetracosanedioic acid, 3,22-dicarboxy-9,16-dioxo-, 1,24-bis(phenylmethyl) ester, (3S,22S)-

There total 1 articles about 2,8,17,23-Tetraazatetracosanedioic acid, 3,22-dicarboxy-9,16-dioxo-, 1,24-bis(phenylmethyl) ester, (3S,22S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.7%

N2-[(benzyloxy)carbonyl]-L-lysine (2212-75-1) + disuccinimidyl suberate (68528-80-3) → 2-(benzyloxycarbonylamino)-6-(7-(5-(benzyloxycarbonylamino)-5-carboxypentylaminocarbonyl)heptanoylamino)hexanoic acid (675587-73-2)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2003.12.001

Reference yield:

2-(benzyloxycarbonylamino)-6-(7-(5-(benzyloxycarbonylamino)-5-carboxypentylaminocarbonyl)heptanoylamino)hexanoic acid (675587-73-2) → (S)-6-{7-[(S)-5-Carboxy-5-(5-dimethylaminomethyl-2,4-dinitro-phenylamino)-pentylcarbamoyl]-heptanoylamino}-2-(5-dimethylaminomethyl-2,4-dinitro-phenylamino)-hexanoic acid

Guidance literature:

Multi-step reaction with 2 steps

1: 92.9 percent / formic acid / Pd/C / methanol / 3 h / 20 °C

2: phosphate buffer / dimethylformamide / pH 7.0

With formic acid; phosphate buffer; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2003.12.001

upstream raw materials:

N₂-[(benzyloxy)carbonyl]-L-lysine

disuccinimidyl suberate