2-amino-7-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6-(methylsulfanyl)-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine-5-carboxamide

Base Information

Chemical Name:2-amino-7-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6-(methylsulfanyl)-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine-5-carboxamide
CAS No.:127945-63-5
Molecular Formula:C₁₂H₁₇N₅O₅S
Molecular Weight:343.363
Hs Code.:
Mol file:127945-63-5.mol

Synonyms:1H-Pyrrolo[2,3-d]pyrimidine-5-carboxamide,2-amino-4,7-dihydro-7-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6-(methylthio)-4-oxo-(9CI)

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-amino-7-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6-(methylsulfanyl)-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine-5-carboxamide

Chemical Property:

Vapor Pressure:2.1E-22mmHg at 25°C
Boiling Point:730.6°Cat760mmHg
Flash Point:395.6°C
Density:1.78g/cm³

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-amino-7-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6-(methylsulfanyl)-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine-5-carboxamide

There total 3 articles about 2-amino-7-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6-(methylsulfanyl)-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 127945-47-5
2-amino-5-(aminocarbonyl)-6-(methylthio)-7-<<1,3-bis(benzyloxy)-2-propoxy>methyl>pyrrolo<2,3-d>pyrimidin-4-one

: 127945-63-5
2-amino-5-(aminocarbonyl)-6-(methylthio)-7-<(1,3-dihydroxy-2-propoxy)methyl>pyrrolo<2,3-d>pyrimidin-4-one

Guidance literature:: With boron trichloride; In dichloromethane; at -78 ℃; for 4h;
DOI:10.1021/jm00170a019

Reference yield:

: 38187-09-6
2-amino-3,4-bis(aminocarbonyl)-5-(methylthio)pyrrole

: 127945-63-5
2-amino-5-(aminocarbonyl)-6-(methylthio)-7-<(1,3-dihydroxy-2-propoxy)methyl>pyrrolo<2,3-d>pyrimidin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, RT, 5 min, 2.) RT, 3 h

3: 63 percent / BCl₃ / CH₂Cl₂ / 4 h / -78 °C

With boron trichloride; sodium hydride; In dichloromethane;
DOI:10.1021/jm00170a019

Reference yield:

: 127945-32-8
1-<<1,3-bis(benzyloxy)-2-propoxy>methyl>-2-amino-3,4-bis(aminocarbonyl)-5-(methylthio)pyrrole

: 127945-63-5
2-amino-5-(aminocarbonyl)-6-(methylthio)-7-<(1,3-dihydroxy-2-propoxy)methyl>pyrrolo<2,3-d>pyrimidin-4-one

Guidance literature:: Multi-step reaction with 2 steps

2: 63 percent / BCl₃ / CH₂Cl₂ / 4 h / -78 °C

With boron trichloride; In dichloromethane;
DOI:10.1021/jm00170a019