2-(3,4-Dimethoxyphenyl)acetohydrazide

Base Information

• Chemical Name: 2-(3,4-Dimethoxyphenyl)acetohydrazide
• CAS No.: 60075-23-2
• Molecular Formula: C10H14N2O3
• Molecular Weight: 210.233
• Hs Code.: 2928009090
• European Community (EC) Number: 672-269-8
• NSC Number: 135965
• DSSTox Substance ID: DTXSID30300328
• Wikidata: Q82043298
• Mol file: 60075-23-2.mol

Synonyms:2-(3,4-Dimethoxyphenyl)acetohydrazide;60075-23-2;3,4-Dimethoxyphenylacetic acid hydrazide;3,4-Dimethoxyphenylacethydrazide;3,4-Dimethoxyphenyl acetic hydrazide;NSC135965;Homoveratric hydrazide;Maybridge1_007491;Oprea1_148441;SCHEMBL602779;HMS562M11;DTXSID30300328;AMY15159;STR08758;BBL000234;CCG-51627;MFCD00051701;STK014585;AKOS000117518;NSC-135965;SB85902;2-(3,4-dimethoxyphenyl)acetic hydrazide;2-(3,4-Dimethoxyphenyl)acetohydrazide #;MS-10952;Benzeneacetic acid,3,4-dimethoxy-,hydrazide;CS-0150514;FT-0614351;(3,4-dimethoxy-phenyl)-acetic acid hydrazide;D94703;A832590;SR-01000640918-1

Chemical Property of 2-(3,4-Dimethoxyphenyl)acetohydrazide

Chemical Property:

• Vapor Pressure: 2.84E-07mmHg at 25°C
• Melting Point: 102-104°C
• Refractive Index: 1.538
• Boiling Point: 420.3 °C at 760 mmHg
• Flash Point: 208 °C
• PSA: 73.58000
• Density: 1.168 g/cm³
• LogP: 1.32740
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 0
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 210.10044231
• Heavy Atom Count: 15
• Complexity: 211

Purity/Quality:

99% ^*data from raw suppliers

3,4-DimethoxyphenylaceticAcidHydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)CC(=O)NN)OC

Technology Process of 2-(3,4-Dimethoxyphenyl)acetohydrazide

There total 5 articles about 2-(3,4-Dimethoxyphenyl)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl (3,4-dimethoxyphenyl)acetate (15964-79-1) → 3,4-dimethoxyphenylacetic acid hydrazide (60075-23-2)

Guidance literature:

With hydrazine hydrate; at 110 - 120 ℃;

DOI:10.1039/b110414d

Reference yield: 75.0%

3,4-dimethoxyphenylacetyl chloride (10313-60-7) → 3,4-dimethoxyphenylacetic acid hydrazide (60075-23-2)

Guidance literature:

With hydrazine hydrate; triethylamine; In acetonitrile; for 3h; Reflux;

DOI:10.2174/1573406410666140327142912

Reference yield: 75.0%

→ 3,4-dimethoxyphenylacetic acid hydrazide (60075-23-2)

Guidance literature:

With triethylamine; hydrazine; In water; acetonitrile; for 3h; Reflux;

upstream raw materials:

ethyl 3,4-dimethoxyphenylacetate

methyl (3,4-dimethoxyphenyl)acetate

3,4-dimethoxyphenylacetyl chloride

(3,4-Dimethoxyphenyl)acetic acid

Downstream raw materials:

(3,4-dimethoxy-phenyl)-acetic acid N'-(4-phenyl-4,5,6,7-tetrahydro-3H-[1,4]diazepin-2-yl)-hydrazide

4-(5-(3,4-dimethoxybenzyl)-1,3,4-thiadiazol-2-yl)benzene-1,3-diol

6-bromomethyl-3-(3,4-dimethoxyphenyl)chromen-2-one

Refernces

• 1、 -. "Novel triazole derivative with anti-inflammatory and anti-hyperglycemic activity and method for preparing the same". Paragraph 0075; 0087. . Retrieved 2017/08/23.
• 2、 Wujec, Monika,Stefanska, Joanna,Siwek, Agata,Tatarczak, Malgorzata. "Synthesis, lipophilicity and antimicrobial activity of new derivatives of thiosemicarbazides and 1,2,4-triazoline-5-thione". body text. p. 73 - 82. Retrieved 2009/06/19.