3-Iodo-1-tosyl-1h-indole-5-carbonitrile

Base Information

• Chemical Name: 3-Iodo-1-tosyl-1h-indole-5-carbonitrile
• CAS No.: 676273-39-5
• Molecular Formula: C16H11IN2O2S
• Molecular Weight: 422.246
• Mol file: 676273-39-5.mol

Synonyms:3-Iodo-1-(toluene-4-sulfonyl)-1H-indole-5-carbonitrile;3-Iodo-1-tosyl-1h-indole-5-carbonitrile;

Chemical Property of 3-Iodo-1-tosyl-1h-indole-5-carbonitrile

Chemical Property:

• PSA: 71.24000
• LogP: 4.74378
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

3-Iodo-1-tosyl-1H-indole-5-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Iodo-1-tosyl-1h-indole-5-carbonitrile

There total 3 articles about 3-Iodo-1-tosyl-1h-indole-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.5%

3-iodo-1H-indole-5-carbonitrile (1092114-59-4) + p-toluenesulfonyl chloride (98-59-9) → 3-iodo-1-tosyl-1H-indole-5-carbonitrile (676273-39-5)

Guidance literature:

3-iodo-1H-indole-5-carbonitrile; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;

p-toluenesulfonyl chloride; In mineral iol; N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield: 95.0%

1H-indole-5-carbonitrile (15861-24-2,142396-06-3) → 3-iodo-1-tosyl-1H-indole-5-carbonitrile (676273-39-5)

Guidance literature:

With potassium penicillin V; sodium thiosulfate; In N,N-dimethyl-formamide;

Reference yield: 92.0%

1H-indole-5-carbonitrile (15861-24-2,142396-06-3) + p-toluenesulfonyl chloride (98-59-9) → 3-iodo-1-tosyl-1H-indole-5-carbonitrile (676273-39-5)

Guidance literature:

1H-indole-5-carbonitrile; With iodine; potassium hydroxide; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

p-toluenesulfonyl chloride; With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 15h;

DOI:10.1021/acs.joc.9b02471

upstream raw materials:

3-iodo-1H-indole-5-carbonitrile

p-toluenesulfonyl chloride

1H-indole-5-carbonitrile

Downstream raw materials:

1-(Toluene-4-sulfonyl)-3-tributylstannanyl-1H-indole-5-carbonitrile

C₂₄H₁₆N₂O₂S₂

2-[5-Cyano-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-cyclopent-1-ene Carboxylic Acid Ethyl Ester

N'-hydroxy-3-iodo-1-tosyl-1H-indole-5-carboximidamide

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