Benzoic acid, 3-[[dimethyl(1,1,2-trimethylpropyl)silyl]oxy]-2-[[[(2R)-2-[(5-hydroxy-1-oxo pentyl)amino]-3-methoxy-3-oxopropyl]thio]methyl]-5-methoxy-6-methyl-

Base Information

Chemical Name:Benzoic acid, 3-[[dimethyl(1,1,2-trimethylpropyl)silyl]oxy]-2-[[[(2R)-2-[(5-hydroxy-1-oxo pentyl)amino]-3-methoxy-3-oxopropyl]thio]methyl]-5-methoxy-6-methyl-
CAS No.:676347-24-3
Molecular Formula:C₂₇H₄₅NO₈SSi
Molecular Weight:571.808
Hs Code.:

Benzoic acid,
3-[[dimethyl(1,1,2-trimethylpropyl)silyl]oxy]-2-[[[(2R)-2-[(5-hydroxy-1-oxo
pentyl)amino]-3-methoxy-3-oxopropyl]thio]methyl]-5-methoxy-6-methyl-

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Chemical Property of Benzoic acid, 3-[[dimethyl(1,1,2-trimethylpropyl)silyl]oxy]-2-[[[(2R)-2-[(5-hydroxy-1-oxo pentyl)amino]-3-methoxy-3-oxopropyl]thio]methyl]-5-methoxy-6-methyl-

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Technology Process of Benzoic acid, 3-[[dimethyl(1,1,2-trimethylpropyl)silyl]oxy]-2-[[[(2R)-2-[(5-hydroxy-1-oxo pentyl)amino]-3-methoxy-3-oxopropyl]thio]methyl]-5-methoxy-6-methyl-

There total 13 articles about Benzoic acid, 3-[[dimethyl(1,1,2-trimethylpropyl)silyl]oxy]-2-[[[(2R)-2-[(5-hydroxy-1-oxo pentyl)amino]-3-methoxy-3-oxopropyl]thio]methyl]-5-methoxy-6-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 111-29-5
1 ,5-pentanediol

: 676347-24-3
(R)-3-[dimethyl(thexyl)silyloxy]-2-[2-(5-hydroxypentanoylamino)-2-(methoxycarbonyl)ethylsulfanylmethyl]-5-methoxy-6-methylbenzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 47 percent / pyridine / 16.5 h / 0 - 20 °C

2: 75 percent / DMSO; (COCl)2; Et₃N / CH₂Cl₂ / 1.33 h / -70 - 10 °C

3: 78 percent / aq. KMnO₄ / acetone / 2 h / 20 °C

4: EDC / acetonitrile / 8 h / 0 °C

5: 79.2 g / pTsOH*H₂O; MeOH / 3 h / 20 °C

6: morpholine; Pd(PPh₃)4 / tetrahydrofuran / 2 h / 0 °C

With morpholine; pyridine; methanol; potassium permanganate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; toluene-4-sulfonic acid; dimethyl sulfoxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; dichloromethane; acetone; acetonitrile;
DOI:10.1021/jm0310232

Reference yield:

: 52344-94-2
methyl 3,5-dimethoxy-2-methylbenzoate

: 676347-24-3
(R)-3-[dimethyl(thexyl)silyloxy]-2-[2-(5-hydroxypentanoylamino)-2-(methoxycarbonyl)ethylsulfanylmethyl]-5-methoxy-6-methylbenzoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: 92 percent / POCl₃ / CH₂Cl₂ / 72 h / 40 °C

2.1: 86 percent / BCl₃ / CH₂Cl₂ / 4.5 h / 20 °C

3.1: 98 percent / aq. KOH / 0.5 h / 75 °C

4.1: N,N,N',N'-tetramethylguanidine / dimethylformamide / 0.5 h

4.2: 86 percent / dimethylformamide / 3 h

5.1: 90 percent / Et₃N / dimethylformamide / 6 h

6.1: 66 percent / TFA; Et₃SiH / 0.5 h / 0 °C

7.1: EDC / acetonitrile / 8 h / 0 °C

8.1: 79.2 g / pTsOH*H₂O; MeOH / 3 h / 20 °C

9.1: morpholine; Pd(PPh₃)4 / tetrahydrofuran / 2 h / 0 °C

With morpholine; methanol; triethylsilane; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron trichloride; toluene-4-sulfonic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; trichlorophosphate; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1.1: Vilsmeyer formylation;
DOI:10.1021/jm0310232

Reference yield:

: 67373-56-2
chlorodimethyl(1,1,2-trimethylpropyl)silane

: 676347-24-3
(R)-3-[dimethyl(thexyl)silyloxy]-2-[2-(5-hydroxypentanoylamino)-2-(methoxycarbonyl)ethylsulfanylmethyl]-5-methoxy-6-methylbenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / Et₃N / dimethylformamide / 6 h

2: 66 percent / TFA; Et₃SiH / 0.5 h / 0 °C

3: EDC / acetonitrile / 8 h / 0 °C

4: 79.2 g / pTsOH*H₂O; MeOH / 3 h / 20 °C

5: morpholine; Pd(PPh₃)4 / tetrahydrofuran / 2 h / 0 °C

With morpholine; methanol; triethylsilane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; toluene-4-sulfonic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm0310232