Benzoic acid, 2-[[[(2R)-2-(acetylamino)-3-methoxy-3-oxopropyl]thio]methyl]-3-[[dimeth yl(1,1,2-trimethylpropyl)silyl]oxy]-5-methoxy-6-methyl-, methyl ester

Base Information

Chemical Name:Benzoic acid, 2-[[[(2R)-2-(acetylamino)-3-methoxy-3-oxopropyl]thio]methyl]-3-[[dimeth yl(1,1,2-trimethylpropyl)silyl]oxy]-5-methoxy-6-methyl-, methyl ester
CAS No.:676347-26-5
Molecular Formula:C25H41NO7SSi
Molecular Weight:527.755
Hs Code.:

Benzoic acid,
2-[[[(2R)-2-(acetylamino)-3-methoxy-3-oxopropyl]thio]methyl]-3-[[dimeth
yl(1,1,2-trimethylpropyl)silyl]oxy]-5-methoxy-6-methyl-, methyl ester

Synonyms:

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Chemical Property of Benzoic acid, 2-[[[(2R)-2-(acetylamino)-3-methoxy-3-oxopropyl]thio]methyl]-3-[[dimeth yl(1,1,2-trimethylpropyl)silyl]oxy]-5-methoxy-6-methyl-, methyl ester

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Technology Process of Benzoic acid, 2-[[[(2R)-2-(acetylamino)-3-methoxy-3-oxopropyl]thio]methyl]-3-[[dimeth yl(1,1,2-trimethylpropyl)silyl]oxy]-5-methoxy-6-methyl-, methyl ester

There total 5 articles about Benzoic acid, 2-[[[(2R)-2-(acetylamino)-3-methoxy-3-oxopropyl]thio]methyl]-3-[[dimeth yl(1,1,2-trimethylpropyl)silyl]oxy]-5-methoxy-6-methyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 7652-46-2
Ac-Cys-OMe

: 173153-62-3
methyl 2-formyl-5-methoxy-6-methyl-3-[dimethyl(thexyl)silyloxy]benzoate

: methyl 2,6-dimethyl-3-[dimethyl(thexyl)silanyloxy]-5-methoxybenzoate

: 676347-26-5
methyl (R)-2-[2-acetylamino-2-(methoxycarbonyl)ethylsulfanylmethyl]-3-[dimethyl(thexyl)silyloxy]-5-methoxy-6-methylbenzoate

Guidance literature:: With triethylsilane; trifluoroacetic acid; at 0 ℃; for 18h;
DOI:10.1021/jm0310232

Reference yield:

: 52344-94-2
methyl 3,5-dimethoxy-2-methylbenzoate

: 676347-26-5
methyl (R)-2-[2-acetylamino-2-(methoxycarbonyl)ethylsulfanylmethyl]-3-[dimethyl(thexyl)silyloxy]-5-methoxy-6-methylbenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / POCl₃ / CH₂Cl₂ / 72 h / 40 °C

2: 86 percent / BCl₃ / CH₂Cl₂ / 4.5 h / 20 °C

3: 90 percent / Et₃N / dimethylformamide / 6 h

4: 69 percent / TFA; Et₃SiH / 18 h / 0 °C

With triethylsilane; boron trichloride; triethylamine; trifluoroacetic acid; trichlorophosphate; In dichloromethane; N,N-dimethyl-formamide; 1: Vilsmeyer formylation;
DOI:10.1021/jm0310232

Reference yield:

: 67373-56-2
chlorodimethyl(1,1,2-trimethylpropyl)silane

: 676347-26-5
methyl (R)-2-[2-acetylamino-2-(methoxycarbonyl)ethylsulfanylmethyl]-3-[dimethyl(thexyl)silyloxy]-5-methoxy-6-methylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / Et₃N / dimethylformamide / 6 h

2: 69 percent / TFA; Et₃SiH / 18 h / 0 °C

With triethylsilane; triethylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm0310232