tert-butyl [(2S,3R)-4-{[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-{4-[2-(1H-imidazol-1-yl)ethoxy]phenyl}butyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate

Base Information

Chemical Name:tert-butyl [(2S,3R)-4-{[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-{4-[2-(1H-imidazol-1-yl)ethoxy]phenyl}butyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate
CAS No.:162540-49-0
Molecular Formula:C₃₅H₅₁N₅O₇
Molecular Weight:653.819
Hs Code.:
Mol file:162540-49-0.mol

tert-butyl [(2S,3R)-4-{[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-{4-[2-(1H-imidazol-1-yl)ethoxy]phenyl}butyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate

Synonyms:12-Oxa-2,6,10-triazatetradecanoicacid,4,8-dihydroxy-3-[[4-[2-(1H-imidazol-1-yl)ethoxy]phenyl]methyl]-13,13-dimethyl-11-oxo-9-(phenylmethyl)-,1,1-dimethylethyl ester, [3S-(3R*,4S*,8S*,9R*)]-

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Chemical Property of tert-butyl [(2S,3R)-4-{[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-{4-[2-(1H-imidazol-1-yl)ethoxy]phenyl}butyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate

Chemical Property:

Vapor Pressure:5.89E-30mmHg at 25°C
Boiling Point:840°Cat760mmHg
PKA:11.89±0.46(Predicted)
Flash Point:461.8°C
PSA：163.18000
Density:1.18g/cm³
LogP:4.64500

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-butyl [(2S,3R)-4-{[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-{4-[2-(1H-imidazol-1-yl)ethoxy]phenyl}butyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate

There total 10 articles about tert-butyl [(2S,3R)-4-{[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-{4-[2-(1H-imidazol-1-yl)ethoxy]phenyl}butyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 246047-29-0
((S)-3-Amino-1-benzyl-2-hydroxy-propyl)-carbamic acid tert-butyl ester

: {(S)-2-[4-(2-Imidazol-1-yl-ethoxy)-phenyl]-1-oxiranyl-ethyl}-carbamic acid tert-butyl ester

: 162540-49-0
{(S)-3-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-1-[4-(2-imidazol-1-yl-ethoxy)-benzyl]-propyl}-carbamic acid tert-butyl ester

Guidance literature:: In N,N-dimethyl-formamide; at 100 ℃; for 4.5h;
DOI:10.1021/jm950717a

Reference yield:

: 2130-96-3,54784-43-9
O-benzyl-N-tert-butoxycarbonyl-L-tyrosine

: 162540-49-0
{(S)-3-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-1-[4-(2-imidazol-1-yl-ethoxy)-benzyl]-propyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 4-methylmorpholine / tetrahydrofuran

2: tetrahydrofuran; diethyl ether / 0 °C

3: HCl / dioxane / 0 °C

4: NaBH₄

5: KOH / ethanol

6: 99 percent / H₂, Pd(OH)2/C / ethanol; ethyl acetate / 4.5 h

7: 86 percent / diethyl azodicarboxylate, Ph₃P / tetrahydrofuran / 18 h / Ambient temperature

8: 27 percent / dimethylformamide / 4.5 h / 100 °C

With 4-methyl-morpholine; hydrogenchloride; palladium dihydroxide; potassium hydroxide; sodium tetrahydroborate; hydrogen; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm950717a

Reference yield:

: 1026977-99-0
C₂₆H₃₃NO₇

: 162540-49-0
{(S)-3-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-1-[4-(2-imidazol-1-yl-ethoxy)-benzyl]-propyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran; diethyl ether / 0 °C

2: HCl / dioxane / 0 °C

3: NaBH₄

4: KOH / ethanol

5: 99 percent / H₂, Pd(OH)2/C / ethanol; ethyl acetate / 4.5 h

6: 86 percent / diethyl azodicarboxylate, Ph₃P / tetrahydrofuran / 18 h / Ambient temperature

7: 27 percent / dimethylformamide / 4.5 h / 100 °C

With hydrogenchloride; palladium dihydroxide; potassium hydroxide; sodium tetrahydroborate; hydrogen; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm950717a