2-Formyl-3,5-dimethoxy-4-methyl-N,N-bis(1-methylethyl)benzamide

Base Information

Chemical Name:2-Formyl-3,5-dimethoxy-4-methyl-N,N-bis(1-methylethyl)benzamide
CAS No.:676541-51-8
Molecular Formula:C17H25NO4
Molecular Weight:307.39
Hs Code.:
DSSTox Substance ID:DTXSID701174182

Synonyms:676541-51-8;DTXSID701174182;2-Formyl-3,5-dimethoxy-4-methyl-N,N-bis(1-methylethyl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Formyl-3,5-dimethoxy-4-methyl-N,N-bis(1-methylethyl)benzamide

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:307.17835828
Heavy Atom Count:22
Complexity:375

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C=C(C(=C1OC)C=O)C(=O)N(C(C)C)C(C)C)OC

Technology Process of 2-Formyl-3,5-dimethoxy-4-methyl-N,N-bis(1-methylethyl)benzamide

There total 3 articles about 2-Formyl-3,5-dimethoxy-4-methyl-N,N-bis(1-methylethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 159429-49-9
N,N-diisopropyl-3,5-dimethoxy-4-methylbenzamide

: 676541-51-8
2-formyl-N,N-diisopropyl-3,5-dimethoxy-4-methylbenzamide

Guidance literature:: N,N-diisopropyl-3,5-dimethoxy-4-methylbenzamide; With sec.-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

Fe(CO)5; In tetrahydrofuran; at -78 - 20 ℃; for 11h;
DOI:10.1021/jo0356210

Reference yield:

: 61040-81-1
4-methyl-3,5-dimethoxybenzoic acid

: 676541-51-8
2-formyl-N,N-diisopropyl-3,5-dimethoxy-4-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: SOCl₂ / 80 °C

2.1: 12.9 g / CH₂Cl₂ / 14 h / 20 °C

3.1: s-BuLi / tetrahydrofuran / 1 h / -78 °C

3.2: 92 percent / tetrahydrofuran / 11 h / -78 - 20 °C

With thionyl chloride; sec.-butyllithium; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0356210

Reference yield:

: 34523-76-7
3,5-dimethoxy-4-methylbenzoyl chloride

: 676541-51-8
2-formyl-N,N-diisopropyl-3,5-dimethoxy-4-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 12.9 g / CH₂Cl₂ / 14 h / 20 °C

2.1: s-BuLi / tetrahydrofuran / 1 h / -78 °C

2.2: 92 percent / tetrahydrofuran / 11 h / -78 - 20 °C

With sec.-butyllithium; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0356210