1,7,8-trifluoronaphthalen-2-ol

Base Information

Chemical Name:1,7,8-trifluoronaphthalen-2-ol
CAS No.:676545-61-2
Molecular Formula:C10H5F3O
Molecular Weight:
Hs Code.:

Synonyms:

Suppliers and Price of 1,7,8-trifluoronaphthalen-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 1,7,8-trifluoronaphthalen-2-ol

Chemical Property:

Vapor Pressure:0.00117mmHg at 25°C

Purity/Quality:: 99.3% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1,7,8-trifluoronaphthalen-2-ol

There total 9 articles about 1,7,8-trifluoronaphthalen-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1,7,8-trifluoronaphthalen-2-yl acetate

: 676545-61-2
1,7,8-trifluoronaphthalen-2-ol

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; for 1.5h; Inert atmosphere;
DOI:10.1002/ange.202006489

Reference yield:

: 676545-62-3
1,1,7,8-tetrafluoro-1,2-dihydronaphthalen-2-one

: 676545-61-2
1,7,8-trifluoronaphthalen-2-ol

Guidance literature:: With hydrogen; silica gel; 5%-palladium/activated carbon; In ethyl acetate; at 20 ℃; for 4h; under 2942.29 Torr; Autoclave;

Reference yield:

: 348-61-8
1-bromo-3,4-difluorobenzene

: 676545-61-2
1,7,8-trifluoronaphthalen-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1.25 h / -78 °C

1.2: 0.5 h / -78 °C

2.1: sodium tetrahydroborate / ethanol / 0.5 h / 0 °C / Inert atmosphere

3.1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine; pyridine hydrogenfluoride / dichloromethane / 7 h / 20 - 80 °C / Inert atmosphere

4.1: triphenylphosphine; potassium carbonate; palladium dichloride / tetrahydrofuran; water / 12 h / 85 °C

5.1: sodium hydroxide / water; methanol / 1.5 h / 20 °C

6.1: dmap; pyridine / toluene / 12.5 h / Reflux

7.1: potassium carbonate / methanol / 0.5 h / 20 °C

With pyridine; dmap; sodium tetrahydroborate; 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine; potassium carbonate; pyridine hydrogenfluoride; triphenylphosphine; sodium hydroxide; palladium dichloride; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene; 4.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.jfluchem.2013.11.005