3-Hydroxyretinol

Base Information

Chemical Name:3-Hydroxyretinol
CAS No.:6890-93-3
Molecular Formula:C20H30 O2
Molecular Weight:302.457
Hs Code.:
UNII:065F06X5YW
DSSTox Substance ID:DTXSID901316912
Nikkaji Number:J593.404D
Mol file:6890-93-3.mol

Synonyms:3-hydroxyretinol

Suppliers and Price of 3-Hydroxyretinol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-Hydroxyl-retinol
10mg
$ 3310.00

TRC
3-Hydroxyl-retinol
5mg
$ 1840.00

TRC
3-Hydroxyl-retinol
2.5mg
$ 1025.00

American Custom Chemicals Corporation
ALL-TRANS 3-HYDROXYRETINOL 95.00%
1MG
$ 818.61

Total 8 raw suppliers

Chemical Property of 3-Hydroxyretinol

Chemical Property:

Vapor Pressure:1.88E-10mmHg at 25°C
Boiling Point:461.4°C at 760 mmHg
Flash Point:205.7°C
PSA：40.46000
Density:1.018g/cm³
LogP:4.48110
XLogP3:4.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:302.224580195
Heavy Atom Count:22
Complexity:528

Purity/Quality:

97% ^*data from raw suppliers

3-Hydroxyl-retinol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(CC(C1)O)(C)C)C=CC(=CC=CC(=CCO)C)C
Isomeric SMILES:CC1=C(C(CC(C1)O)(C)C)/C=C/C(=C/C=C/C(=C/CO)/C)/C
Uses 3-Hydroxyl-retinol is a derivative product of all-trans-retinol (R252000) that occurs preformed only in animals; metabolized from carotenoids, such β-carotene, in the intestinal mucosa. Dietary sources include liver, milk, butter, cheese, eggs and fish liver oils or as carotenois from fruits and vegetables. Stored primarily in the liver in esterified form; transported in the blood by retinol binding protein (RBP). Nutritional factor.

Technology Process of 3-Hydroxyretinol

There total 21 articles about 3-Hydroxyretinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76686-34-5,76739-85-0,120674-74-0,120674-75-1,120674-76-2,120685-61-2
(2E,4E,6Z,8E)-9-(4-Hydroxy-2,6,6-trimethyl-cyclohex-1-enyl)-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid ethyl ester

: 6890-93-3,60046-52-8,106623-46-5,106623-47-6,120674-70-6,120674-71-7,120674-72-8,120674-73-9,120674-87-5,120674-88-6
4-((1E,3Z,5E,7E)-9-Hydroxy-3,7-dimethyl-nona-1,3,5,7-tetraenyl)-3,5,5-trimethyl-cyclohex-3-enol

Guidance literature:: With diisobutylaluminium hydride; In diethyl ether; at -78 ℃;
DOI:10.1021/ja00375a048

Reference yield:

: 14398-35-7
(3E)-4-(2,6,6-trimethylcyclohexa-1,3-dien-1-yl)but-3-en-2-one

: 6890-93-3,60046-52-8,106623-46-5,106623-47-6,120674-70-6,120674-71-7,120674-72-8,120674-73-9,120674-87-5,120674-88-6
4-((1E,3Z,5E,7E)-9-Hydroxy-3,7-dimethyl-nona-1,3,5,7-tetraenyl)-3,5,5-trimethyl-cyclohex-3-enol

Guidance literature:: Multi-step reaction with 8 steps

1: 70 percent / p-TsOH / benzene / Heating

2: 1.) 9-BBN, 2.) NaOH, H₂O₂ / 1.) 55-60 deg C

3: 90 percent / Im*DMF / Ambient temperature

4: 90 percent / HCl / acetone

5: 1.) LDA, 2.) HCO₂H / 1.) THF, -78 deg C, 2.) room temperature

6: 85 percent / NaH / tetrahydrofuran / -10 °C

7: n-Bu₄N(+)F(-) / tetrahydrofuran / Ambient temperature

8: Dibal / diethyl ether / -78 °C

With hydrogenchloride; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; formic acid; tetrabutyl ammonium fluoride; dihydrogen peroxide; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; acetone; benzene;
DOI:10.1021/ja00375a048

Reference yield:

: 39760-56-0,3917-43-9,41891-54-7
triethyl 3-methyl-4-phosphonocrotonate

: 6890-93-3,60046-52-8,106623-46-5,106623-47-6,120674-70-6,120674-71-7,120674-72-8,120674-73-9,120674-87-5,120674-88-6
4-((1E,3Z,5E,7E)-9-Hydroxy-3,7-dimethyl-nona-1,3,5,7-tetraenyl)-3,5,5-trimethyl-cyclohex-3-enol

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / NaH / tetrahydrofuran / -10 °C

2: n-Bu₄N(+)F(-) / tetrahydrofuran / Ambient temperature

3: Dibal / diethyl ether / -78 °C

With tetrabutyl ammonium fluoride; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ja00375a048