Chemical Property of Lificiguat
Chemical Property:
- Melting Point:110-112℃
- Boiling Point:522.2±50.0 °C(Predicted)
- PKA:13.83±0.10(Predicted)
- PSA：51.19000
- Density:1.24±0.1 g/cm3(Predicted)
- LogP:3.83690
- Storage Temp.:-20C
- Solubility.:DMSO: 12 mg/mL
- XLogP3:3.1
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:4
- Exact Mass:304.121177757
- Heavy Atom Count:23
- Complexity:386
- Purity/Quality:
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99%, *data from raw suppliers
YC-1 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=N2)C4=CC=C(O4)CO
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Description
YC-1 (170632-47-0) is a nitric oxide-independent activator of soluble guanylyl cyclase (sGC). Significantly elevates cGMP levels and inhibits collagen-stimulated aggregation of rabbit platelets (IC50?= 14.6 μM).1?Induces human endometrial cancer cell senescence via modulation of HIF1α activity.2?Induces degradation of HIF1α.3?Protects against glutamate-induced neuronal damage4?and β-amyloid-induced toxicity in differentiated PC12 cells5.
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Uses
YC-1 has been used as a hypoxia-inducible factor 1α (HIF-1α) inhibitor:to reduce hypoxia induced Jagged1 expression in cardiomyocytes (CMs)to study its effect on progenitor expansion and CD34+ and side population (SP) cell phenotype and on the proliferation rate of cells with an ability to form long term colony forming unitsto study its effect on regulating sphingosine 1-phosphate (S1P) bound to albumin induced plasminogen activator inhibitor 1 (PAI-1) expression by activating Rho/ Rho-associated protein kinase (ROCK) pathway.
