1'-benzyl 1-tert-butyl spiro[indoline-3,4'-piperidine]-1,1'-dicarboxylate

Base Information

• Chemical Name: 1'-benzyl 1-tert-butyl spiro[indoline-3,4'-piperidine]-1,1'-dicarboxylate
• CAS No.: 676607-30-0
• Molecular Formula: C25H30N2O4
• Molecular Weight: 422.524
• Mol file: 676607-30-0.mol

Synonyms:

Chemical Property of 1'-benzyl 1-tert-butyl spiro[indoline-3,4'-piperidine]-1,1'-dicarboxylate

Chemical Property:

• PSA: 59.08000
• LogP: 5.11500

Purity/Quality:

97% ^*data from raw suppliers

1'-Benzyl 1-tert-butyl spiro[indoline-3,4'-piperidine]-1,1'-dicarboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1'-benzyl 1-tert-butyl spiro[indoline-3,4'-piperidine]-1,1'-dicarboxylate

There total 4 articles about 1'-benzyl 1-tert-butyl spiro[indoline-3,4'-piperidine]-1,1'-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + benzyl spiro[indoline-3,4’-piperidine]-1‘-carboxylate (167484-18-6) → 1'-benzyloxycarbonyl-1-tert-butyloxycarbonylspiro[indoline-3,4'-piperidine] (676607-30-0)

Guidance literature:

benzyl spiro[indoline-3,4’-piperidine]-1‘-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.166667h;

di-tert-butyl dicarbonate; In N,N-dimethyl-formamide; mineral oil; for 4h;

Reference yield:

N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde (138163-08-3) → 1'-benzyloxycarbonyl-1-tert-butyloxycarbonylspiro[indoline-3,4'-piperidine] (676607-30-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / toluene; acetonitrile / 20 - 50 °C

1.2: 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

2.2: 4 h

With sodium hydride; trifluoroacetic acid; In N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

Reference yield:

4-fluorophenyhydrazine hydrochloride (823-85-8) → 1'-benzyloxycarbonyl-1-tert-butyloxycarbonylspiro[indoline-3,4'-piperidine] (676607-30-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / toluene; acetonitrile / 20 - 50 °C

1.2: 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

2.2: 4 h

With sodium hydride; trifluoroacetic acid; In N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

upstream raw materials:

4-fluorophenyhydrazine hydrochloride

di-tert-butyl dicarbonate

benzyl spiro[indoline-3,4’-piperidine]-1‘-carboxylate

N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde

Downstream raw materials:

tert-butyl spiro[indoline-3,4'-piperidine]-1-carboxylate