2-Hexenoic acid, 4-[[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-methoxyphenyl)-3- methyl-1-oxobutyl]methylamino]-2,5-dimethyl-, ethyl ester, (2E,4S)-

Base Information

Chemical Name:2-Hexenoic acid, 4-[[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-methoxyphenyl)-3- methyl-1-oxobutyl]methylamino]-2,5-dimethyl-, ethyl ester, (2E,4S)-
CAS No.:676629-25-7
Molecular Formula:C₂₈H₄₄N₂O₆
Molecular Weight:504.667
Hs Code.:

2-Hexenoic acid,
4-[[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-methoxyphenyl)-3-
methyl-1-oxobutyl]methylamino]-2,5-dimethyl-, ethyl ester, (2E,4S)-

Synonyms:

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Chemical Property of 2-Hexenoic acid, 4-[[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-methoxyphenyl)-3- methyl-1-oxobutyl]methylamino]-2,5-dimethyl-, ethyl ester, (2E,4S)-

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Technology Process of 2-Hexenoic acid, 4-[[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-methoxyphenyl)-3- methyl-1-oxobutyl]methylamino]-2,5-dimethyl-, ethyl ester, (2E,4S)-

There total 3 articles about 2-Hexenoic acid, 4-[[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-methoxyphenyl)-3- methyl-1-oxobutyl]methylamino]-2,5-dimethyl-, ethyl ester, (2E,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 676629-25-7
(E)-(S)-4-{[(S)-2-tert-Butoxycarbonylamino-3-(4-methoxy-phenyl)-3-methyl-butyryl]-methyl-amino}-2,5-dimethyl-hex-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaHCO₃

2: PyBOP; DIEA / CH₂Cl₂

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2004.05.077

Reference yield:

: (S)-2-Amino-3-(4-methoxy-phenyl)-3-methyl-butyric acid

: 676629-25-7
(E)-(S)-4-{[(S)-2-tert-Butoxycarbonylamino-3-(4-methoxy-phenyl)-3-methyl-butyryl]-methyl-amino}-2,5-dimethyl-hex-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaHCO₃

2: PyBOP; DIEA / CH₂Cl₂

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2004.05.077

Reference yield:

: 676631-15-5
2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-3-methyl-butyric acid

: ethyl (2E,4S)-Nmethyl-4-amino-2,5-dimethylhex-2-enoate hydrochloride

: 676629-25-7
(E)-(S)-4-{[(S)-2-tert-Butoxycarbonylamino-3-(4-methoxy-phenyl)-3-methyl-butyryl]-methyl-amino}-2,5-dimethyl-hex-2-enoic acid ethyl ester

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2004.05.077