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Technology Process of 6,9-Difluoro-11-hydroxy-3,20-dioxopregna-1,4-diene-17,21-diyl diacetate

6,9-Difluoro-11-hydroxy-3,20-dioxopregna-1,4-diene-17,21-diyl diacetate

Base Information
  • Chemical Name:6,9-Difluoro-11-hydroxy-3,20-dioxopregna-1,4-diene-17,21-diyl diacetate
  • CAS No.:23641-05-6
  • Molecular Formula:C25H30F2O7
  • Molecular Weight:480.506
  • Hs Code.:
  • DSSTox Substance ID:DTXSID10946460
  • Mol file:23641-05-6.mol
6,9-Difluoro-11-hydroxy-3,20-dioxopregna-1,4-diene-17,21-diyl diacetate

Synonyms:6,9-difluoro-11-hydroxy-3,20-dioxopregna-1,4-diene-17,21-diyl diacetate;DTXSID10946460

Suppliers and Price of 6,9-Difluoro-11-hydroxy-3,20-dioxopregna-1,4-diene-17,21-diyl diacetate
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
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Total 8 raw suppliers
Chemical Property of 6,9-Difluoro-11-hydroxy-3,20-dioxopregna-1,4-diene-17,21-diyl diacetate
Chemical Property:
  • Vapor Pressure:6.5E-16mmHg at 25°C 
  • Melting Point:280-283 °C 
  • Boiling Point:580.9°Cat760mmHg 
  • PKA:12.63±0.70(Predicted) 
  • Flash Point:305.1°C 
  • PSA：106.97000 
  • Density:1.33g/cm3 
  • LogP:2.73930 
  • XLogP3:2.6
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:9
  • Rotatable Bond Count:6
  • Exact Mass:480.19595962
  • Heavy Atom Count:34
  • Complexity:1020
Purity/Quality:

99% *data from raw suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:
Useful:
  • Canonical SMILES:CC(=O)OCC(=O)C1(CCC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)OC(=O)C
Technology Process of 6,9-Difluoro-11-hydroxy-3,20-dioxopregna-1,4-diene-17,21-diyl diacetate

There total 3 articles about 6,9-Difluoro-11-hydroxy-3,20-dioxopregna-1,4-diene-17,21-diyl diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Acetic acid (6S,9R,17R)-17-(2-acetoxy-acetyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester
23641-05-6,60864-46-2

Acetic acid (6S,9R,17R)-17-(2-acetoxy-acetyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester

Guidance literature:
Triol (31), Ueberfuehrung ins Bis-Acetat;
DOI:10.1021/jm00212a006

Reference yield:

9α,6α-Difluorprednisolon-17,21-diacetat
23641-05-6,60864-46-2

9α,6α-Difluorprednisolon-17,21-diacetat

Guidance literature:
entspr. Hydrocortison, DDQ;

Reference yield:

Acetic acid (9R,17R)-17-(2-acetoxy-acetyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester
23641-05-6,60864-46-2

Acetic acid (9R,17R)-17-(2-acetoxy-acetyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester

Guidance literature:
Epoxid (26a), 70percentige HF;
DOI:10.1021/jm00212a006
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