Chemical Property of Spirapril hydrochloride
Chemical Property:
- Appearance/Colour:White Solid
- Vapor Pressure:1.93E-20mmHg at 25°C
- Melting Point:192-194°C
- Boiling Point:697.8 °C at 760 mmHg
- Flash Point:375.8 °C
- PSA：146.54000
- LogP:3.52160
- Storage Temp.:-20°C Freezer
- Solubility.:Very slightly soluble in water, soluble in methanol, slightly soluble in acetonitrile, practically insoluble in methylene chloride.
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:8
- Rotatable Bond Count:10
- Exact Mass:502.1362921
- Heavy Atom Count:32
- Complexity:650
- Purity/Quality:
-
97% *data from raw suppliers
SpiraprilHydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CC3(CC2C(=O)O)SCCS3.Cl
- Isomeric SMILES:CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2CC3(C[C@H]2C(=O)O)SCCS3.Cl
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Description
Spirapril hydrochloride is a new ACE inhibitor introduced in Finland for
the treatment of hypertension. Spirapril is orally active and rapidly absorbed and
converted to the active diacid spiraprilat which produces a reduction in blood pressure
similar to that seen with enalapril and captopril. Spirapril has been reported to be well
tolerated and exhibits an apparently lower incidence of cough compared with other ACE
inhibitors. The elimination of spirapril occurs via both renal and hepatic routes so that
no dosage adjustment is required for patients with renal impairment. In patients with
severe congestive heart failure, spirapril has demonstrated beneficial hemodynamic
effects with a duration of action >24 hours.
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Uses
Angiotensin-converting enzyme (ACE) inhibior. Antihypertensive. Angiotensin-converting enzyme (ACE) inhibior. Antihypertensive
