1H-Isoindol-1-one, 2,3-dihydro-2-[(1R)-2-hydroxy-1-[4-(phenylmethoxy)phenyl]ethyl]-3-prop yl-, (3R)-

Base Information

Chemical Name:1H-Isoindol-1-one, 2,3-dihydro-2-[(1R)-2-hydroxy-1-[4-(phenylmethoxy)phenyl]ethyl]-3-prop yl-, (3R)-
CAS No.:677009-88-0
Molecular Formula:C₂₆H₂₇NO₃
Molecular Weight:401.505
Hs Code.:

Synonyms:

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Chemical Property of 1H-Isoindol-1-one, 2,3-dihydro-2-[(1R)-2-hydroxy-1-[4-(phenylmethoxy)phenyl]ethyl]-3-prop yl-, (3R)-

Chemical Property:

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Technology Process of 1H-Isoindol-1-one, 2,3-dihydro-2-[(1R)-2-hydroxy-1-[4-(phenylmethoxy)phenyl]ethyl]-3-prop yl-, (3R)-

There total 3 articles about 1H-Isoindol-1-one, 2,3-dihydro-2-[(1R)-2-hydroxy-1-[4-(phenylmethoxy)phenyl]ethyl]-3-prop yl-, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 677009-96-0
2-[(R)-1-(4-Benzyloxy-phenyl)-2-hydroxy-ethyl]-3-hydroxy-3-propyl-2,3-dihydro-isoindol-1-one

: 677009-88-0
(3R,1'R)-3-n-propyl-2-[2-hydroxy-1-(4-benzyloxyphenyl)ethyl]-2,3-dihydro-1H-isoindolin-1-one

: (3S,1'R)-3-n-propyl-2-[2-hydroxy-1-(4-benzyloxyphenyl)ethyl]-2,3-dihydro-1H-isoindolin-1-one

Guidance literature:: With triethylsilane; boron trifluoride diethyl etherate; In dichloromethane; at -78 ℃; for 6h;
DOI:10.1016/j.tet.2003.11.092

Reference yield:

: 69489-40-3
D-2-[p-(benzyloxy)phenyl]glycine

: 677009-88-0
(3R,1'R)-3-n-propyl-2-[2-hydroxy-1-(4-benzyloxyphenyl)ethyl]-2,3-dihydro-1H-isoindolin-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: LiAlH₄ / tetrahydrofuran / Heating

2: 79 percent / 15 h / 170 - 180 °C

3: 93 percent / diethyl ether; CH₂Cl₂ / 4 h / -15 - -10 °C

4: Et₃SiH; BF₃*OEt₂ / CH₂Cl₂ / 6 h / -78 °C

With triethylsilane; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; In tetrahydrofuran; diethyl ether; dichloromethane; 3: Grignard reaction;
DOI:10.1016/j.tet.2003.11.092

Reference yield:

: 289051-79-2
(R)-2-hyrdoxy-1-(4-benzyloxyphenyl)ethylamine

: 677009-88-0
(3R,1'R)-3-n-propyl-2-[2-hydroxy-1-(4-benzyloxyphenyl)ethyl]-2,3-dihydro-1H-isoindolin-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / 15 h / 170 - 180 °C

2: 93 percent / diethyl ether; CH₂Cl₂ / 4 h / -15 - -10 °C

3: Et₃SiH; BF₃*OEt₂ / CH₂Cl₂ / 6 h / -78 °C

With triethylsilane; boron trifluoride diethyl etherate; In diethyl ether; dichloromethane; 2: Grignard reaction;
DOI:10.1016/j.tet.2003.11.092