1H-Indole-2-carboxylic acid, 5-[(2R)-2-[[(2R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-[4-hydroxy-3-( hydroxymethyl)phenyl]ethyl]amino]propyl]-

Base Information

Chemical Name:1H-Indole-2-carboxylic acid, 5-[(2R)-2-[[(2R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-[4-hydroxy-3-( hydroxymethyl)phenyl]ethyl]amino]propyl]-
CAS No.:677026-90-3
Molecular Formula:C27H38N2O5Si
Molecular Weight:498.695
Hs Code.:

1H-Indole-2-carboxylic acid,
5-[(2R)-2-[[(2R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-[4-hydroxy-3-(
hydroxymethyl)phenyl]ethyl]amino]propyl]-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Indole-2-carboxylic acid, 5-[(2R)-2-[[(2R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-[4-hydroxy-3-( hydroxymethyl)phenyl]ethyl]amino]propyl]-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Indole-2-carboxylic acid, 5-[(2R)-2-[[(2R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-[4-hydroxy-3-( hydroxymethyl)phenyl]ethyl]amino]propyl]-

There total 1 articles about 1H-Indole-2-carboxylic acid, 5-[(2R)-2-[[(2R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-[4-hydroxy-3-( hydroxymethyl)phenyl]ethyl]amino]propyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 677026-91-4
methyl 5-[(2R)-2-({(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)propyl]-1H-indole-2-carboxylate

: 677026-90-3
5-[(2R)-2-({(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-[4-hydroxy-3-(hydroxy methyl)phenyl]ethyl}amino)propyl]-1H-indole-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; water; at 20 - 90 ℃; for 1h;

Reference yield:

: 677026-90-3
5-[(2R)-2-({(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-[4-hydroxy-3-(hydroxy methyl)phenyl]ethyl}amino)propyl]-1H-indole-2-carboxylic acid

: 757963-27-2
5-[(2R)-2-({(2R)-2-Hydroxy-2-(4-hydroxy-3-hydroxymethyl phenyl)ethyl} amino)propyl]-N-(2-trifluoromethoxybenzyl)-1H-indole-2-carboxamide

Guidance literature:: 5-[(2R)-2-({(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-[4-hydroxy-3-(hydroxy methyl)phenyl]ethyl}amino)propyl]-1H-indole-2-carboxylic acid; With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 2-(trifluoromethoxy)benzylamine; butan-1-ol; In DMF (N,N-dimethyl-formamide);

With ammonium fluoride; In methanol; water; at 40 ℃;

Reference yield:

: 677026-90-3
5-[(2R)-2-({(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-[4-hydroxy-3-(hydroxy methyl)phenyl]ethyl}amino)propyl]-1H-indole-2-carboxylic acid

: 757963-56-7
5-[(2R)-2-({(2R)-2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl)ethyl} amino)propyl]-N-(4-methylsulfamoylbenzyl)-1H-indole-2-carboxamide

Guidance literature:: 5-[(2R)-2-({(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-[4-hydroxy-3-(hydroxy methyl)phenyl]ethyl}amino)propyl]-1H-indole-2-carboxylic acid; With pyridine; 4-(aminomethyl)-N-methylbenzenesulfonamide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; butan-1-ol; In DMF (N,N-dimethyl-formamide); for 12h;

With ammonium fluoride; In methanol; water; at 40 ℃; for 12h;