4-Deoxy-4-fluoro-beta-d-glucopyranose

Base Information

Chemical Name:4-Deoxy-4-fluoro-beta-d-glucopyranose
CAS No.:62182-11-0
Molecular Formula:C₆H₁₁FO₅
Molecular Weight:182.149
Hs Code.:2932999099
DSSTox Substance ID:DTXSID40977762
Nikkaji Number:J37.021E
Wikidata:Q82963057
Mol file:62182-11-0.mol

Synonyms:4-deoxy-4-fluoro-beta-D-glucopyranose

Suppliers and Price of 4-Deoxy-4-fluoro-beta-d-glucopyranose

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 10 raw suppliers

Chemical Property of 4-Deoxy-4-fluoro-beta-d-glucopyranose

Chemical Property:

Vapor Pressure:5.52E-07mmHg at 25°C
Refractive Index:1.535
Boiling Point:370.1 °C at 760 mmHg
Flash Point:170.1 °C
PSA：90.15000
Density:1.59 g/cm³
LogP:-2.24420
Storage Temp.:2-8°C
XLogP3:-2.1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:182.05905161
Heavy Atom Count:12
Complexity:155

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C(C1C(C(C(C(O1)O)O)O)F)O
Isomeric SMILES:C([C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)O)O)F)O

Technology Process of 4-Deoxy-4-fluoro-beta-d-glucopyranose

There total 7 articles about 4-Deoxy-4-fluoro-beta-d-glucopyranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1,6-anhydro-2-O-benzyl-4-deoxy-4-fluoro-β-D-glucopyranose

: 27108-04-9
4-deoxy-4-fluoro-β-D-glucopyranose

: 62182-11-0
3-fluoro-3-deoxy-α-D-glucose

Guidance literature:: With boron trichloride; In dichloromethane; at 0 - 20 ℃; for 2h; Overall yield = 85 percent; Overall yield = 18.7 mg; Inert atmosphere;
DOI:10.1002/chem.202002825

Reference yield:

: 3601-36-3,6344-46-3
methyl 2,3,6-tri-O-benzoyl-α-D-galactopyranoside

: 62182-11-0
3-fluoro-3-deoxy-α-D-glucose

Guidance literature:: Multi-step reaction with 3 steps

1: 56 percent / diethylaminosulfur trifluoride, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1) -20 deg C, 15 min, 2) RT, 24 h

2: 78 percent / 1M NaOMe in MeOH / 18 h / Ambient temperature

3: H₂O, Dowex 50W-X₈(1+)> / 25 h / Heating

With dmap; diethylamino-sulfur trifluoride; Dowex 50W-X8; water; sodium methylate; In dichloromethane;
DOI:10.1016/S0008-6215(00)90028-4

Reference yield:

: 498-07-7
levoglucosan

: 27108-04-9
4-deoxy-4-fluoro-β-D-glucopyranose

: 62182-11-0
3-fluoro-3-deoxy-α-D-glucose

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / toluene / 23 h / 0 - 20 °C / Inert atmosphere

2.1: sodium methylate / dichloromethane; methanol / 2 h / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 0 - 20 °C / Inert atmosphere

3.1: tetra-n-butylammoniumfluoride trihydrate; potassium hydrogen bifluoride / 3 h / 180 °C / Inert atmosphere

4.1: boron trichloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With pyridine; potassium hydrogen bifluoride; sodium methylate; boron trichloride; tetra-n-butylammoniumfluoride trihydrate; In methanol; dichloromethane; toluene;
DOI:10.1002/chem.202002825