Hpmpa

Base Information

Chemical Name:Hpmpa
CAS No.:92999-29-6
Molecular Formula:C₉H₁₄N₅O₅P
Molecular Weight:303.214
Hs Code.:
UNII:CJC8PO1KQ3
DSSTox Substance ID:DTXSID20239219
Nikkaji Number:J228.060D
Wikipedia:HPMPA
Wikidata:Q15411034
ChEMBL ID:CHEMBL286534
Mol file:92999-29-6.mol

Synonyms:(S)-HPMPA;9-(3-hydroxy-2-phosphonomethoxypropyl)adenine;9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine;9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine, (+-)-isomer;9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine, (R)-isomer;9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine, 14C-labeled, (S)-isomer;9-(S)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine;HPMPA

Suppliers and Price of Hpmpa

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(S)-(((1-(6-Amino-9H-purin-9-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphonicacid 95+%
100mg
$ 337.00

Crysdot
(S)-(((1-(6-Amino-9H-purin-9-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphonicacid 95+%
250mg
$ 540.00

Crysdot
(S)-(((1-(6-Amino-9H-purin-9-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphonicacid 95+%
1g
$ 1350.00

Chemenu
(S)-(((1-(6-amino-9H-purin-9-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphonicacid 95%
1g
$ 1262.00

American Custom Chemicals Corporation
9-(3-HYDROXY-2-PHOSPHONYL-METHOXYPROPYL)-ADENINE 95.00%
5MG
$ 496.79

Total 7 raw suppliers

Chemical Property of Hpmpa

Chemical Property:

Vapor Pressure:9.82E-22mmHg at 25°C
Melting Point:255-257 °C
Boiling Point:719.6°Cat760mmHg
PKA:2.31±0.10(Predicted)
Flash Point:389°C
PSA：166.42000
Density:1.91g/cm³
LogP:-0.49760
XLogP3:-2.6
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:6
Exact Mass:303.07325556
Heavy Atom Count:20
Complexity:369

Purity/Quality:

97% ^*data from raw suppliers

(S)-(((1-(6-Amino-9H-purin-9-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphonicacid 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=NC(=C2C(=N1)N(C=N2)CC(CO)OCP(=O)(O)O)N
Isomeric SMILES:C1=NC(=C2C(=N1)N(C=N2)C[C@@H](CO)OCP(=O)(O)O)N

Technology Process of Hpmpa

There total 20 articles about Hpmpa which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 148873-55-6
diisopropyl (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine

: 92999-29-6,92924-62-4,115226-05-6,121552-05-4
(S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine

Guidance literature:: With hydrogenchloride; In water; at 130 - 140 ℃; Microwave irradiation; Sealed tube;
DOI:10.1039/c2gc35547g

Reference yield: 75.0%

: 115268-98-9
Chloromethyl-phosphonic acid mono-[(S)-3-(6-amino-purin-9-yl)-2-hydroxy-propyl] ester

: 92999-29-6,92924-62-4,115226-05-6,121552-05-4
(S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine

Guidance literature:: With sodium hydroxide;

Reference yield:

: 54262-83-8
(S)-9-(2,3-dihydroxypropyl)adenine

: 92999-29-6,92924-62-4,115226-05-6,121552-05-4
(S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine

Guidance literature:: Multi-step reaction with 2 steps

1.1: DCC; pyridine / 16 h

2.1: NaH; DMF / 6 h

2.2: H₂O / 3 h

With pyridine; sodium hydride; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide;
DOI:10.1016/j.bmcl.2003.12.107