4-Bromo-8-nitroisoquinoline

Base Information

• Chemical Name: 4-Bromo-8-nitroisoquinoline
• CAS No.: 677702-62-4
• Molecular Formula: C9H5BrN2O2
• Molecular Weight: 253.055
• Mol file: 677702-62-4.mol

Synonyms:

Chemical Property of 4-Bromo-8-nitroisoquinoline

Chemical Property:

• Boiling Point: 379.9±27.0 °C(Predicted)
• PKA: 1.56±0.24(Predicted)
• PSA: 58.71000
• Density: 1.747±0.06 g/cm3(Predicted)
• LogP: 3.42870
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-8-nitroisoquinoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromo-8-nitroisoquinoline

There total 1 articles about 4-Bromo-8-nitroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromoisoquinoline (1532-97-4) → 4-bromo-8-nitroisoquinoline (677702-62-4) + 4-bromo-5-nitro-isoquinoline (58142-46-4)

Guidance literature:

With sulfuric acid; nitric acid; In water; at 20 ℃; for 3h; Product distribution / selectivity;

Reference yield:

4-bromo-8-nitroisoquinoline (677702-62-4) + (3,5-dichlorophenyl)boronic acid (67492-50-6) → 4-(3,5-dichlorophenyl)-8-nitro-isoquinoline

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,4-dioxane; water; at 80 ℃; for 3h; Inert atmosphere;

Reference yield:

4-bromo-8-nitroisoquinoline (677702-62-4) → 4-bromo-[8]isoquinolylamine (351458-46-3)

Guidance literature:

With hydrogenchloride; tin(ll) chloride; In ethanol; for 1h; Heating / reflux;

upstream raw materials:

4-bromoisoquinoline

Downstream raw materials:

4-bromo-[8]isoquinolylamine