N-(3,N'-morpholinopropyl)-2-(3-nitropyrrolo-(2,3-b)pyridine-1-yl)ethanoic acid amide

Base Information

• Chemical Name: N-(3,N'-morpholinopropyl)-2-(3-nitropyrrolo-(2,3-b)pyridine-1-yl)ethanoic acid amide
• CAS No.: 110231-01-1
• Molecular Formula: C16H21 N5 O4
• Molecular Weight: 347.374
• Hs Code.: 2934999090
• Mol file: 110231-01-1.mol

Synonyms:N-(3,N’-morpholinopropyl)-2-(3-nitropyrrolo-(2,3-b)pyridine-1-yl)ethanoic acid amide

Chemical Property of N-(3,N'-morpholinopropyl)-2-(3-nitropyrrolo-(2,3-b)pyridine-1-yl)ethanoic acid amide

Chemical Property:

• Boiling Point: 628°Cat760mmHg
• Flash Point: 333.6°C
• PSA: 108.70000
• Density: 1.41g/cm³
• LogP: 2.08440

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(3,N'-morpholinopropyl)-2-(3-nitropyrrolo-(2,3-b)pyridine-1-yl)ethanoic acid amide

There total 2 articles about N-(3,N'-morpholinopropyl)-2-(3-nitropyrrolo-(2,3-b)pyridine-1-yl)ethanoic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-(3-Aminopropyl)morpholine (123-00-2) + ethyl 2-(3-nitropyrrolo<2,3-b>pyridin-1-yl) ethanoate (127988-45-8) → N-(3, N'-morpholinopropyl)-2-(3-nitropyrrolo<2,3-b>pyridin-1-yl) ethanoic acid amide (110231-01-1)

Guidance literature:

In ethanol; for 3h; Heating;

DOI:10.1016/0223-5234(89)90056-1

Reference yield:

3-nitro-1H-pyrrolo<2,3-b>pyridine (23709-47-9) → N-(3, N'-morpholinopropyl)-2-(3-nitropyrrolo<2,3-b>pyridin-1-yl) ethanoic acid amide (110231-01-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / potassium carbonate / acetonitrile / 1.5 h / Heating

2: 87 percent / ethanol / 3 h / Heating

With potassium carbonate; In ethanol; acetonitrile;

DOI:10.1016/0223-5234(89)90056-1

upstream raw materials:

4-(3-Aminopropyl)morpholine

ethyl 2-(3-nitropyrrolo<2,3-b>pyridin-1-yl) ethanoate

3-nitro-1H-pyrrolo<2,3-b>pyridine

Refernces