5-FLUORO-2-METHYLBENZENESULFONYL CHLORIDE

Base Information

• Chemical Name: 5-FLUORO-2-METHYLBENZENESULFONYL CHLORIDE
• CAS No.: 445-05-6
• Molecular Formula: C7H6ClFO2S
• Molecular Weight: 208.641
• Hs Code.: 29049090
• Mol file: 445-05-6.mol

Synonyms:o-Toluenesulfonylchloride, 5-fluoro- (6CI,8CI);2-Methyl-5-fluorobenzenesulfonyl chloride;3-Fluoro-6-methylbenzenesulfonyl chloride;

Chemical Property of 5-FLUORO-2-METHYLBENZENESULFONYL CHLORIDE

Chemical Property:

• Appearance/Colour: clear colorless to yellow liquid
• Melting Point: 123-125 °C
• Refractive Index: n20/D 1.5355(lit.)
• Boiling Point: 266.1 °C at 760 mmHg
• Flash Point: 114.7 °C
• PSA: 42.52000
• Density: 1.423 g/cm³
• LogP: 3.14240
• Sensitive.: Moisture Sensitive

Purity/Quality:

99% ^*data from raw suppliers

5-Fluoro-2-methylbenzenesulfonyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34-29
• Safety Statements: 23-26-36/37/39-45-22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Fluoro-2-methylbenzenesulfonyl chloride may be used to synthesize 1-(aminomethyl)-5-fluoro-N,N-dimethyl-benzenesulfonamide.

Technology Process of 5-FLUORO-2-METHYLBENZENESULFONYL CHLORIDE

There total 4 articles about 5-FLUORO-2-METHYLBENZENESULFONYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-fluoro-6-methylaniline (367-29-3) → 5-fluoro-2-methylbenzenesulfonyl chloride (445-05-6)

Guidance literature:

With tert.-butylnitrite; sulfur dioxide; N-benzyl-N,N,N-triethylammonium chloride; ethylene glycol; copper dichloride; In dichloromethane; acetonitrile; at 0 - 20 ℃; Automated synthesizer;

DOI:10.1039/c0ob00450b

Reference yield:

p-fluorotoluene (352-32-9) → 5-fluoro-2-methylbenzenesulfonyl chloride (445-05-6)

Guidance literature:

With chlorosulfonic acid;

Reference yield:

→ 5-fluoro-2-methylbenzenesulfonyl chloride (445-05-6)

Guidance literature:

With phosphorus pentachloride;

upstream raw materials:

p-fluorotoluene

3-fluoro-6-methylaniline

Downstream raw materials:

5-Fluoro-2-methyl-benzenesulfonic acid 2-chloro-phenyl ester

2-phenyl-6-(2-methyl-5-fluorophenyl)-1,3,4-oxadiazolo<3,2-a>-s-triazine-5,7-dithione

2-p-chlorophenyl-6-(2-methyl-5-fluorophenyl)-1,3,4-oxadiazolo<3,2-a>-s-triazine-5,7-dithione

2-p-methoxyphenyl-6-(2-methyl-5-fluorophenyl)-1,3,4-oxadiazolo<3,2-a>-s-triazine-5,7-dithione

Refernces

• 1、 Malet-Sanz, Laia,Madrzak, Julia,Ley, Steven V.,Baxendale, Ian R.. "Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor". experimental part. p. 5324 - 5332. Retrieved 2011/01/12.
• 2、 Nizamuddin,Giri,Gupta. "Synthesis of some aryl fluorobenzene sulphonates and hydroxy diaryl sulphones as potential fungicides". . p. 365 - 366. Retrieved 2007/10/02.