3-(2-((5-methyl-2-phenyloxazol-4-yl)methyl)benzofuran-5-yl)-2-(propylsulfanyl)propionic acid

Base Information

• Chemical Name: 3-(2-((5-methyl-2-phenyloxazol-4-yl)methyl)benzofuran-5-yl)-2-(propylsulfanyl)propionic acid
• CAS No.: 150563-61-4
• Molecular Formula: C25H25 N O4 S
• Molecular Weight: 435.54
• Mol file: 150563-61-4.mol

Synonyms:3-(2-((5-methyl-2-phenyloxazol-4-yl)methyl)benzofuran-5-yl)-2-(propylsulfanyl)propionic acid

Chemical Property of 3-(2-((5-methyl-2-phenyloxazol-4-yl)methyl)benzofuran-5-yl)-2-(propylsulfanyl)propionic acid

Chemical Property:

• Vapor Pressure: 2.98E-16mmHg at 25°C
• Boiling Point: 620.4°Cat760mmHg
• PKA: 3.63±0.46(Predicted)
• Flash Point: 329°C
• PSA: 101.77000
• Density: 1.24g/cm³
• LogP: 6.12590

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-((5-methyl-2-phenyloxazol-4-yl)methyl)benzofuran-5-yl)-2-(propylsulfanyl)propionic acid

There total 9 articles about 3-(2-((5-methyl-2-phenyloxazol-4-yl)methyl)benzofuran-5-yl)-2-(propylsulfanyl)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

ethyl 3-[2-((5-Methyl-2-phenyl-4-oxazolyl)-methyl)benzofuran-5-yl]-2-(propylthio)-propanoate (140129-27-7) → 3-[2-((5-methyl-2-phenyl-4-oxazolyl)methyl)benzofuran-5-yl]-2-(propylthio)-propanoic Acid (150563-61-4)

Guidance literature:

With sodium hydroxide; In methanol; for 2h; Heating;

DOI:10.1021/jm960230h

Reference yield:

4-bromoacetyl-5-methyl-2-phenyl-oxazole (103788-62-1) → 3-[2-((5-methyl-2-phenyl-4-oxazolyl)methyl)benzofuran-5-yl]-2-(propylthio)-propanoic Acid (150563-61-4)

Guidance literature:

Multi-step reaction with 7 steps

1: 85 percent / diisopropylethylamine / dimethylformamide / 3 h / 91 - 94 °C

2: 100 percent / NaBH₄ / methanol; tetrahydrofuran / 2 h / 0 °C

3: 95 percent / Et₃SiH, TFA / 1.) 0 deg C, 1.5 h, 2.) RT, overnight

4: 80 percent / H₂ / PtO₂ / ethyl acetate / 1.25 h / 2068.6 Torr

5: 1.) 48percent aq. HBr, sodium nitrite, 2.) Cu₂O / 1.) acetone, methanol, from 0 to 5 deg C, 15 min, 2.) acetone, methanol, 1 h

6: 87 percent / K₂CO₃ / dimethylformamide / Ambient temperature

7: 70 percent / aq. NaOH / methanol / 2 h / Heating

With copper(I) oxide; triethylsilane; sodium hydroxide; sodium tetrahydroborate; hydrogen bromide; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium nitrite; platinum(IV) oxide; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm960230h

Reference yield:

5-Nitrosalicylaldehyde (97-51-8) → 3-[2-((5-methyl-2-phenyl-4-oxazolyl)methyl)benzofuran-5-yl]-2-(propylthio)-propanoic Acid (150563-61-4)

Guidance literature:

Multi-step reaction with 7 steps

1: 85 percent / diisopropylethylamine / dimethylformamide / 3 h / 91 - 94 °C

2: 100 percent / NaBH₄ / methanol; tetrahydrofuran / 2 h / 0 °C

3: 95 percent / Et₃SiH, TFA / 1.) 0 deg C, 1.5 h, 2.) RT, overnight

4: 80 percent / H₂ / PtO₂ / ethyl acetate / 1.25 h / 2068.6 Torr

5: 1.) 48percent aq. HBr, sodium nitrite, 2.) Cu₂O / 1.) acetone, methanol, from 0 to 5 deg C, 15 min, 2.) acetone, methanol, 1 h

6: 87 percent / K₂CO₃ / dimethylformamide / Ambient temperature

7: 70 percent / aq. NaOH / methanol / 2 h / Heating

With copper(I) oxide; triethylsilane; sodium hydroxide; sodium tetrahydroborate; hydrogen bromide; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium nitrite; platinum(IV) oxide; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm960230h

upstream raw materials:

ethyl 3-[2-((5-Methyl-2-phenyl-4-oxazolyl)-methyl)benzofuran-5-yl]-2-(propylthio)-propanoate

4-bromoacetyl-5-methyl-2-phenyl-oxazole

5-Nitrosalicylaldehyde

5-Amino-2-(5-methyl-2-phenyl-4-oxazolyl)-methylbenzofuran

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