2-Thiophenecarboxamide, N-[3-[[4-[2-[[(1,1-dimethylethyl)amino]sulfonyl]-5-(2-methylpropyl)-3-thien yl]phenyl]methyl]-3,4-dihydro-4-oxo-2-propyl-6-quinazolinyl]-N-ethyl-

Base Information

Chemical Name:2-Thiophenecarboxamide, N-[3-[[4-[2-[[(1,1-dimethylethyl)amino]sulfonyl]-5-(2-methylpropyl)-3-thien yl]phenyl]methyl]-3,4-dihydro-4-oxo-2-propyl-6-quinazolinyl]-N-ethyl-
CAS No.:678144-94-0
Molecular Formula:C37H44N4O4S3
Molecular Weight:704.979
Hs Code.:

2-Thiophenecarboxamide,
N-[3-[[4-[2-[[(1,1-dimethylethyl)amino]sulfonyl]-5-(2-methylpropyl)-3-thien
yl]phenyl]methyl]-3,4-dihydro-4-oxo-2-propyl-6-quinazolinyl]-N-ethyl-

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Chemical Property of 2-Thiophenecarboxamide, N-[3-[[4-[2-[[(1,1-dimethylethyl)amino]sulfonyl]-5-(2-methylpropyl)-3-thien yl]phenyl]methyl]-3,4-dihydro-4-oxo-2-propyl-6-quinazolinyl]-N-ethyl-

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Technology Process of 2-Thiophenecarboxamide, N-[3-[[4-[2-[[(1,1-dimethylethyl)amino]sulfonyl]-5-(2-methylpropyl)-3-thien yl]phenyl]methyl]-3,4-dihydro-4-oxo-2-propyl-6-quinazolinyl]-N-ethyl-

There total 5 articles about 2-Thiophenecarboxamide, N-[3-[[4-[2-[[(1,1-dimethylethyl)amino]sulfonyl]-5-(2-methylpropyl)-3-thien yl]phenyl]methyl]-3,4-dihydro-4-oxo-2-propyl-6-quinazolinyl]-N-ethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 5271-67-0
2-Thiophenecarbonyl chloride

: 678144-87-1
N-tert-butyl-3-(4-{[6-(ethylamino)-4-oxo-2-propyl-3,4-dihydroquinazolin-3-yl]methyl}phenyl)-5-isobutylthiophene-2-sulfonamide

: 678144-94-0
thiophene-2-carboxylic acid {3-[4-(2-tert-butylsulfamoyl-5-isobutyl-thiophen-3-yl)-benzyl]-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl}-ethyl-amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm031031i

Reference yield:

: 156483-24-8
3-(4-bromobenzyl)-6-nitro-2-propyl-3,4-dihydroquinazolin-4-one

: 678144-94-0
thiophene-2-carboxylic acid {3-[4-(2-tert-butylsulfamoyl-5-isobutyl-thiophen-3-yl)-benzyl]-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl}-ethyl-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 82 percent / [Pd(Ph₃)4]; NaOH / ethanol; toluene; H₂O / 2 h / 100 °C

2.1: 92 percent / HCO₂NH₄ / Pd/C / methanol / 2.5 h

3.1: acetic acid / 1,2-dichloro-ethane / 0.5 h

3.2: 95 percent / NaB(OAc)3H / 1,2-dichloro-ethane

4.1: 92 percent / DIEA / CH₂Cl₂ / 20 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium formate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; toluene; 1.1: Suzuki coupling;
DOI:10.1021/jm031031i

Reference yield:

: 163520-14-7
5-isobutyl-2 -(tert-butylaminosulfonyl)-3-thiopheneboronic acid

: 678144-94-0
thiophene-2-carboxylic acid {3-[4-(2-tert-butylsulfamoyl-5-isobutyl-thiophen-3-yl)-benzyl]-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl}-ethyl-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 82 percent / [Pd(Ph₃)4]; NaOH / ethanol; toluene; H₂O / 2 h / 100 °C

2.1: 92 percent / HCO₂NH₄ / Pd/C / methanol / 2.5 h

3.1: acetic acid / 1,2-dichloro-ethane / 0.5 h

3.2: 95 percent / NaB(OAc)3H / 1,2-dichloro-ethane

4.1: 92 percent / DIEA / CH₂Cl₂ / 20 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium formate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; toluene; 1.1: Suzuki coupling;
DOI:10.1021/jm031031i