Galactostatin

Base Information

• Chemical Name: Galactostatin
• CAS No.: 107537-94-0
• Molecular Formula: C₆H₁₃NO₅
• Molecular Weight: 179.173
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID50920542
• Nikkaji Number: J93.432A
• Wikidata: Q82893220
• Metabolomics Workbench ID: 98447
• Mol file: 107537-94-0.mol

Synonyms:5-amino-5-deoxygalactopyranose;5-galactosamine;galactostatin

Chemical Property of Galactostatin

Chemical Property:

• Vapor Pressure: 7.48E-08mmHg at 25°C
• Melting Point: 93-95 °C (decomp)
• Boiling Point: 394.3 °C at 760 mmHg
• PKA: 13.46±0.70(Predicted)
• Flash Point: 214.3 °C
• PSA: 113.18000
• Density: 1.643 g/cm³
• LogP: -3.31960
• XLogP3: -2.9
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 1
• Exact Mass: 179.07937252
• Heavy Atom Count: 12
• Complexity: 155

Purity/Quality:

98%min ^*data from raw suppliers

5-AMINO-5-DEOXY-D-GALACTOPYRANOSE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C1C(C(C(C(N1)O)O)O)O)O
• Isomeric SMILES: C([C@@H]1[C@@H]([C@@H]([C@H](C(N1)O)O)O)O)O

Technology Process of Galactostatin

There total 22 articles about Galactostatin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-amino-5-deoxy-D-galactopyranose hydrogensulfite adduct (78698-43-8,81703-56-2,91384-36-0,91384-37-1,109784-32-9,109784-33-0,109784-34-1,109784-35-2,114417-84-4,126575-58-4,130979-29-2,149406-06-4,149406-07-5) → (+)-Galactostatin (107537-94-0)

Guidance literature:

With barium dihydroxide; for 1h; Ambient temperature; pH >/= 8;

DOI:10.1016/S0008-6215(00)90138-1

Reference yield: 92.0%

(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)piperidine-2-sulfonic acid (109784-33-0) → (+)-Galactostatin (107537-94-0)

Guidance literature:

With Dowex-2 x 8 (OH^-) resin; In water;

DOI:10.1271/bbb1961.52.661

Reference yield: 92.0%

(4S,5R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-((4R,5S)-5-formyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (138319-95-6) → (-)-galactostatin (15218-38-9,19130-94-0,62362-40-7,107537-94-0,108147-56-4,109718-63-0,109718-64-1,109718-65-2,121251-50-1,126575-57-3,138382-48-6,149406-05-3)

Guidance literature:

With trifluoroacetic acid; for 0.5h; Ambient temperature;

DOI:10.1039/c39910001576

upstream raw materials:

5-amino-5-deoxy-D-glucose-1-sulfonic acid

5-amino-5-deoxy-D-galactopyranose hydrogensulfite adduct

(+)-galactostatin-1-sulfonic acid

(4R,5S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-((4S,5R)-5-formyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Downstream raw materials:

nojirimycin-δ-lactam

D-galactono-δ-lactam