5-fluoro-2',3'-dideoxycytidine

Base Information

Chemical Name:5-fluoro-2',3'-dideoxycytidine
CAS No.:107036-62-4
Molecular Formula:C9H12 F N3 O3
Molecular Weight:229.211
Hs Code.:
Mol file:107036-62-4.mol

Synonyms:2',3'-Dideoxy-5-fluorocytidine;5-Fluoro-2',3'-dideoxycytidine

Suppliers and Price of 5-fluoro-2',3'-dideoxycytidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Biosynth Carbosynth
2’,3’-Dideoxy-5-fluorocytidine
25 mg
$ 1125.00

Biosynth Carbosynth
2’,3’-Dideoxy-5-fluorocytidine
5 mg
$ 375.00

Biosynth Carbosynth
2’,3’-Dideoxy-5-fluorocytidine
2 mg
$ 250.00

Biosynth Carbosynth
2’,3’-Dideoxy-5-fluorocytidine
10 mg
$ 550.00

American Custom Chemicals Corporation
2',3'-DIDEOXY-5-FLUORO-CYTIDINE 95.00%
5MG
$ 500.49

AK Scientific
Cytidine,2',-3',-dideoxy-5-fluoro-
25mg
$ 1568.00

AK Scientific
Cytidine,2',-3',-dideoxy-5-fluoro-
5mg
$ 556.00

Total 9 raw suppliers

Chemical Property of 5-fluoro-2',3'-dideoxycytidine

Chemical Property:

Vapor Pressure:1.47E-07mmHg at 25°C
Boiling Point:386.2°Cat760mmHg
Flash Point:187.4°C
PSA：91.36000
Density:1.67g/cm³
LogP:-0.02310

Purity/Quality:

99.3% ^*data from raw suppliers

2’,3’-Dideoxy-5-fluorocytidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-fluoro-2',3'-dideoxycytidine

There total 11 articles about 5-fluoro-2',3'-dideoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1-[5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxy-β-D-ribofuranosyl]-5-fluorocytosine

: 107036-62-4
5-fluoro-2',3'-dideoxycytidine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/j.chembiol.2019.04.010

Reference yield: 60.0%

: 107036-61-3
2',3'-dideoxy-5'-O-(trimethylacetyl)-4-thioxo-5-fluorouridine

: 107036-62-4
5-fluoro-2',3'-dideoxycytidine

Guidance literature:: With ammonia; In chloroform; at 138 ℃; for 24h; under 12928.7 Torr;
DOI:10.1021/jm00388a020

Reference yield:

: 32780-06-6
(5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran

: 107036-62-4
5-fluoro-2',3'-dideoxycytidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / dichloromethane / 0 - 20 °C

2.1: diisobutylaluminium hydride / dichloromethane; toluene / 0.75 h / Inert atmosphere; Cooling

2.2: 16 h / 0 - 20 °C

3.1: ethylaluminum dichloride / toluene; 1,2-dichloro-ethane / 16 h / 0 - 20 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; ethylaluminum dichloride; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; toluene;
DOI:10.1002/mrc.4942