5-BroMo-8-fluoroisoquinoline

Base Information

• Chemical Name: 5-BroMo-8-fluoroisoquinoline
• CAS No.: 679433-94-4
• Molecular Formula: C9H5BrFN
• Molecular Weight: 226.048
• Hs Code.: 2933491090
• Mol file: 679433-94-4.mol

Synonyms:QC-7983;

Chemical Property of 5-BroMo-8-fluoroisoquinoline

Chemical Property:

• Boiling Point: 310.3±22.0 °C(Predicted)
• PKA: 3.84±0.36(Predicted)
• PSA: 12.89000
• Density: 1.647±0.06 g/cm3(Predicted)
• LogP: 3.13640
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

NLT 98% ^*data from raw suppliers

5-bromo-8-fluoroisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BroMo-8-fluoroisoquinoline

There total 3 articles about 5-BroMo-8-fluoroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.0%

8-amino-5-bromoisoquinoline (90721-35-0) → 5-bromo-8-fluoroisoquinoline (679433-94-4)

Guidance literature:

8-amino-5-bromoisoquinoline; With tetrafluoroboric acid; sodium nitrite; In water; for 2h;

at 120 ℃; Pyrolysis;

DOI:10.1016/j.bmc.2003.11.015

Reference yield:

5-bromoisoquinoline (34784-04-8) → 5-bromo-8-fluoroisoquinoline (679433-94-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 84.4 percent / KNO₃; H₂SO₄ / 1 h / 0 °C

2.1: NH₄Cl; Fe / methanol; H₂O / 3 h / Heating

3.1: NaNO₂; HBF₄ / H₂O / 2 h

3.2: 3 percent / 120 °C / Pyrolysis

With tetrafluoroboric acid; sulfuric acid; iron; ammonium chloride; potassium nitrate; sodium nitrite; In methanol; water;

DOI:10.1016/j.bmc.2003.11.015

Reference yield:

5-bromo-8-nitroisoquinoline (63927-23-1) → 5-bromo-8-fluoroisoquinoline (679433-94-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NH₄Cl; Fe / methanol; H₂O / 3 h / Heating

2.1: NaNO₂; HBF₄ / H₂O / 2 h

2.2: 3 percent / 120 °C / Pyrolysis

With tetrafluoroboric acid; iron; ammonium chloride; sodium nitrite; In methanol; water;

DOI:10.1016/j.bmc.2003.11.015

upstream raw materials:

8-amino-5-bromoisoquinoline

5-bromoisoquinoline

5-bromo-8-nitroisoquinoline

Refernces

• 1、 -. "INHIBITORS OF JUN N-TERMINAL KINASE". Page/Page column 169. . Retrieved 2010/08/18.