2-Oxa-4,8,12,16,20,25,28-heptaazatriacontane-8,16,20-tricarboxylic acid, 27-(2-amino-2-oxoethyl)-30-[2,4-bis(phenylmethoxy)phenyl]-3,11,26,29- tetraoxo-1-phenyl-, tris(phenylmethyl) ester, (27S)-

Base Information

Chemical Name:2-Oxa-4,8,12,16,20,25,28-heptaazatriacontane-8,16,20-tricarboxylic acid, 27-(2-amino-2-oxoethyl)-30-[2,4-bis(phenylmethoxy)phenyl]-3,11,26,29- tetraoxo-1-phenyl-, tris(phenylmethyl) ester, (27S)-
CAS No.:679812-63-6
Molecular Formula:C74H86N8O14
Molecular Weight:1311.54
Hs Code.:

2-Oxa-4,8,12,16,20,25,28-heptaazatriacontane-8,16,20-tricarboxylic
acid,
27-(2-amino-2-oxoethyl)-30-[2,4-bis(phenylmethoxy)phenyl]-3,11,26,29-
tetraoxo-1-phenyl-, tris(phenylmethyl) ester, (27S)-

Synonyms:

Suppliers and Price of 2-Oxa-4,8,12,16,20,25,28-heptaazatriacontane-8,16,20-tricarboxylic acid, 27-(2-amino-2-oxoethyl)-30-[2,4-bis(phenylmethoxy)phenyl]-3,11,26,29- tetraoxo-1-phenyl-, tris(phenylmethyl) ester, (27S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-Oxa-4,8,12,16,20,25,28-heptaazatriacontane-8,16,20-tricarboxylic acid, 27-(2-amino-2-oxoethyl)-30-[2,4-bis(phenylmethoxy)phenyl]-3,11,26,29- tetraoxo-1-phenyl-, tris(phenylmethyl) ester, (27S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-Oxa-4,8,12,16,20,25,28-heptaazatriacontane-8,16,20-tricarboxylic acid, 27-(2-amino-2-oxoethyl)-30-[2,4-bis(phenylmethoxy)phenyl]-3,11,26,29- tetraoxo-1-phenyl-, tris(phenylmethyl) ester, (27S)-

There total 11 articles about 2-Oxa-4,8,12,16,20,25,28-heptaazatriacontane-8,16,20-tricarboxylic acid, 27-(2-amino-2-oxoethyl)-30-[2,4-bis(phenylmethoxy)phenyl]-3,11,26,29- tetraoxo-1-phenyl-, tris(phenylmethyl) ester, (27S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.6%

: 345898-19-3
4,N⁷-bis(benzyloxycarbonyl)-7-amino-4-azaheptanoic acid succinimidyl ester

: 4,8-bis(benzyloxycarbonyl)-N¹²-{N^α-[2,4-bis(benzyloxy)phenylacetyl]asparaginyl}-4,8-diaza-1,12-dodecanediamine acetate

: 679812-63-6
4,8-bis(benzyloxycarbonyl)-N¹-[4,N⁷-bis(benzyloxycarbonyl)-7-amino-4-azaheptanoyl]-N¹²-{N^α-[2,4-bis(benzyloxy)phenylacetyl]asparaginyl}-4,8-diaza-1,12-dodecanediamine

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1246/bcsj.77.331

Reference yield:

: 177906-29-5
methyl 7-azido-4-benzyloxycarbonyl-4-azaheptanoate

: 679812-63-6
4,8-bis(benzyloxycarbonyl)-N¹-[4,N⁷-bis(benzyloxycarbonyl)-7-amino-4-azaheptanoyl]-N¹²-{N^α-[2,4-bis(benzyloxy)phenylacetyl]asparaginyl}-4,8-diaza-1,12-dodecanediamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: PPh₃ / tetrahydrofuran; H₂O / 30 h / 20 °C

1.2: 71.8 percent / Na₂CO₃ / diethyl ether; tetrahydrofuran; H₂O / 20 °C

2.1: NaOH / H₂O; methanol / 1.5 h / 60 °C

3.1: EDC*HCl / dimethylformamide / 20 °C

4.1: 74.6 percent / Et₃N / dimethylformamide / 18 h / 20 °C

With sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.77.331

Reference yield:

: 177906-28-4
3-[Benzyloxycarbonyl-(3-methanesulfonyloxy-propyl)-amino]-propionic acid methyl ester

: 679812-63-6
4,8-bis(benzyloxycarbonyl)-N¹-[4,N⁷-bis(benzyloxycarbonyl)-7-amino-4-azaheptanoyl]-N¹²-{N^α-[2,4-bis(benzyloxy)phenylacetyl]asparaginyl}-4,8-diaza-1,12-dodecanediamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 7.94 g / NaN₃; (n-Bu)4NBr / toluene; H₂O / 80 °C

2.1: PPh₃ / tetrahydrofuran; H₂O / 30 h / 20 °C

2.2: 71.8 percent / Na₂CO₃ / diethyl ether; tetrahydrofuran; H₂O / 20 °C

3.1: NaOH / H₂O; methanol / 1.5 h / 60 °C

4.1: EDC*HCl / dimethylformamide / 20 °C

5.1: 74.6 percent / Et₃N / dimethylformamide / 18 h / 20 °C

With sodium hydroxide; sodium azide; tetrabutylammomium bromide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1246/bcsj.77.331