Technology Process of Carbonic acid, methyl 1-[(4R)-4-methyl-6-oxo-1-cyclohexen-1-yl]ethyl
ester
There total 3 articles about Carbonic acid, methyl 1-[(4R)-4-methyl-6-oxo-1-cyclohexen-1-yl]ethyl
ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(5R)-2-(1'-hydroxyethyl)-5-methylcyclohex-2-enone;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 - 0 ℃;
for 1h;
carbonic acid dimethyl ester;
In
tetrahydrofuran; hexane;
at 0 - 20 ℃;
for 2h;
Further stages.;
DOI:10.1039/b305880h
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 74 percent / Et2AlI / hexane; CH2Cl2 / 0.5 h / 0 °C
2.1: n-BuLi / hexane; tetrahydrofuran / 1 h / -78 - 0 °C
2.2: 95 percent / hexane; tetrahydrofuran / 2 h / 0 - 20 °C
With
n-butyllithium; diethylaluminum iodide;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1039/b305880h
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 55 percent / CuBr2 / CHCl3; ethyl acetate / 1 h / Heating
2.1: 74 percent / Et2AlI / hexane; CH2Cl2 / 0.5 h / 0 °C
3.1: n-BuLi / hexane; tetrahydrofuran / 1 h / -78 - 0 °C
3.2: 95 percent / hexane; tetrahydrofuran / 2 h / 0 - 20 °C
With
n-butyllithium; diethylaluminum iodide; copper(ll) bromide;
In
tetrahydrofuran; hexane; dichloromethane; chloroform; ethyl acetate;
DOI:10.1039/b305880h
